ALKAL2 - ALK and LTK ligand 2 Gene

Homo sapiens

Also known as AUGA; FAM150B; PRO1097; RGPG542

Gene ID: 285016 | Gene type: protein coding

About ALKAL2

Cytogenetic location: 2p25.3 Genomic coordinates (GRCh38): 2:279,558-288,091 (from NCBI)

This gene has 8 transcripts (splice variants) and 125 orthologues. Biased expression in adrenal (RPKM 46.6), ovary (RPKM 14.2) and 6 other tissues.

Summary

Enables receptor signaling protein tyrosine kinase activator activity and receptor tyrosine kinase binding activity. Involved in positive regulation of ERK1 and ERK2 cascade; positive regulation of ERK5 cascade; and positive regulation of neuron projection development. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

ALKAL2 Products(1)

mRNA	Protein	Name
NM_001002919.3	NP_001002919.2	ALK and LTK ligand 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytokine activity	IDA IDA: Inferred from direct assay	30061385	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26418745	GOA
enables receptor signaling protein tyrosine kinase activator activity	IDA IDA: Inferred from direct assay	26418745	GOA
enables receptor tyrosine kinase binding	IDA IDA: Inferred from direct assay	26418745	GOA
enables transmembrane receptor protein tyrosine kinase activator activity	IDA IDA: Inferred from direct assay	30061385	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell surface receptor protein tyrosine kinase signaling pathway	IDA IDA: Inferred from direct assay	30061385	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	26418745	GOA
involved in positive regulation of ERK5 cascade	IDA IDA: Inferred from direct assay	26418745	GOA
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	26418745	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in extracellular region	IDA IDA: Inferred from direct assay	30061385	GOA
is active in extracellular space	IDA IDA: Inferred from direct assay	30061385	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALKAL2 Protein Structure

FAM150

0
100
152 a.a.

Protein Preferred Names

Protein Names

ALK and LTK ligand 2

AUG-alpha

Related Diseases

Diseases

Alias

Meier-Gorlin Syndrome 4

MGORS4

Meier-Gorlin Syndrome, Type 4

Inflammatory Myofibroblastic Tumor

Inflammatory Fibrosarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00602	ALKAL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ALKAL2	MGD	MGI:3697448
Macaca mulatta	ALKAL2	VGNC	VGNC:82102
Rattus norvegicus	ALKAL2	RGD	RGD:1587117
Bos taurus	ALKAL2	VGNC	VGNC:106637

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