RGCC - regulator of cell cycle Gene

Homo sapiens

Also known as RGC32; RGC-32; C13orf15; bA157L14.2

Gene ID: 28984 | Gene type: protein coding

About RGCC

Cytogenetic location: 13q14.11 Genomic coordinates (GRCh38): 13:41,457,550-41,470,871 (from NCBI)

This gene has 2 transcripts (splice variants) and 194 orthologues. Biased expression in bone marrow (RPKM 99.1), lung (RPKM 65.2) and 11 other tissues.

Summary

This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of Complement System proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with Complement System proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression. [provided by RefSeq, Jul 2008]

RGCC Products(1)

mRNA	Protein	Name
NM_014059.3	NP_054778.2	regulator of cell cycle RGCC

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables R-SMAD binding	IPI IPI: Inferred from physical interaction	21307346	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19162005	GOA
enables protein kinase activator activity	IDA IDA: Inferred from direct assay	11687586	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	11687586	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to hypoxia	IMP IMP: Inferred from mutant phenotype	19652095	GOA
involved in complement activation	IMP IMP: Inferred from mutant phenotype	19162005	GOA
involved in negative regulation of angiogenesis	IDA IDA: Inferred from direct assay	19652095	GOA
involved in negative regulation of blood vessel endothelial cell migration	IDA IDA: Inferred from direct assay	19652095	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17146433	GOA
involved in negative regulation of cell-cell adhesion mediated by cadherin	IDA IDA: Inferred from direct assay	19158077	GOA
involved in negative regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	19162005	GOA
involved in negative regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	19652095	GOA
involved in negative regulation of exit from mitosis	IDA IDA: Inferred from direct assay	17146433	GOA
involved in negative regulation of fibroblast growth factor production	IDA IDA: Inferred from direct assay	19652095	GOA
involved in negative regulation of mitotic cell cycle phase transition	IDA IDA: Inferred from direct assay	17146433	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	19158077	GOA
involved in positive regulation of G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	19162005	GOA
involved in positive regulation of collagen biosynthetic process	IDA IDA: Inferred from direct assay	19158077	GOA
involved in positive regulation of cyclin-dependent protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	11687586	GOA
involved in positive regulation of cyclin-dependent protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	19162005	GOA
involved in positive regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	19162005	GOA
involved in positive regulation of endothelial cell apoptotic process	IDA IDA: Inferred from direct assay	19652095	GOA
involved in positive regulation of epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	21307346	GOA
involved in positive regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	19158077	GOA
involved in positive regulation of extracellular matrix assembly	IDA IDA: Inferred from direct assay	21307346	GOA
involved in positive regulation of extracellular matrix constituent secretion	IDA IDA: Inferred from direct assay	19158077	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	21307346	GOA
involved in positive regulation of mitotic nuclear division	IMP IMP: Inferred from mutant phenotype	19162005	GOA
involved in positive regulation of stress fiber assembly	IDA IDA: Inferred from direct assay	19158077	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19158077	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	17146433	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11687586	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11687586	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGCC Protein Structure

RGCC

0
100
137 a.a.

Protein Preferred Names

Protein Names

regulator of cell cycle RGCC

response gene to complement 32 protein

Related Diseases

Diseases

Alias

Renal Fibrosis

Kahrizi Syndrome

KHRZ	Mental Retardation, Cataract, Coloboma, And Kyphosis, Autosomal Recessive
Intellectual Disability, Kahrizi Type	Intellectual Disability-Cataract-Coloboma-Kyphosis Syndrome

Ischemic Neuropathy

Ischemic Peripheral Neuropathy

Fanconi Anemia, Complementation Group C

Fanconi Anemia Complementation Group C	FANCC
Facc	Fac
Fa3	Fanconi Pancytopenia Type 3
Fanconi Pancytopenia, Type 3	Faces Syndrome
Facial Features , Anorexia, Cachexia, Eye And Skin Anomalies	Friedman-Goodman Syndrome
Abnormality Of The Face

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11889	RGCC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RGCC	VGNC	VGNC:102307
Rattus norvegicus	RGCC	RGD	RGD:619721
Mus musculus	RGCC	MGD	MGI:1913464
Bos taurus	RGCC	VGNC	VGNC:33902
Macaca mulatta	RGCC	VGNC	VGNC:76783

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