2. Gene
  3. GRIN2D - glutamate ionotropic receptor NMDA type subunit 2D Gene

GRIN2D - glutamate ionotropic receptor NMDA type subunit 2D Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EB11; NR2D; DEE46; EIEE46; GluN2D; NMDAR2D

Gene ID: 2906 | Gene type: protein coding

About GRIN2D

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,393,668-48,444,931 (from NCBI)

This gene has 1 transcript (splice variant), 280 orthologues, 17 paralogues and is associated with 3 phenotypes. Low expression observed in reference dataset.

Summary

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA Receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq, Mar 2010]

GRIN2D Products(1)

mRNA Protein Name
NM_000836.4 NP_000827.2 glutamate receptor ionotropic, NMDA 2D precursor

GRIN2D Protein Structure

ANF_receptor

ANF_receptor: Receptor family ligand binding region (136 - 327)

SBP_bac_3

SBP_bac_3: Bacterial extracellular solute-binding proteins, family 3 (485 - 825)

Lig_chan

Lig_chan: Ligand-gated ion channel (584 - 856)

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  • 1336 a.a.
Protein Preferred Names Protein Names

glutamate receptor ionotropic, NMDA 2D

N-methyl D-aspartate receptor subtype 2D

Related Diseases

Diseases Alias
Developmental And Epileptic Encephalopathy 46

DEE46

Epileptic Encephalopathy, Early Infantile, 46

Eiee46

Developmental And Epileptic Encephalopathy, 46

Early Infantile Epileptic Encephalopathy 46
Non-Specific Early-Onset Epileptic Encephalopathy

Undetermined Early-Onset Epileptic Encephalopathy

Non-Specific Eoee

Undetermined Eoee
Fibromyalgia

Diffuse Myofascial Pain Syndrome

Fibromyalgia Syndrome

Fibromyalgia-Fibromyositis Syndrome

Fibromyositis

Fibrositis

Fms

Myofascial Pain Syndrome

Myofascial Pain Syndromes
Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic
High Pressure Neurological Syndrome
Autosomal Dominant Intellectual Developmental Disorder 6

Autosomal Dominant Non-Syndromic Intellectual Disability 6

Autosomal Dominant Mental Retardation 6

Mrd6

Mental Retardation, Autosomal Dominant, Type 6

Mental Retardation, Autosomal Dominant 6
Schizophrenia 7

SCZD7

Schizophrenia Susceptibility Locus, Chromosome 13q-Related

Schizophrenia 7 With Or Without An Affective Disorder
Retinitis Pigmentosa 30

RP30

Retinitis Pigmentosa-30

Retinitis Pigmentosa, Type 30
Landau-Kleffner Syndrome

Acquired Epileptic Aphasia

Lks

Acquired Aphasia With Convulsive Disorder

Acquired Epileptiform Aphasia

Landau Kleffner Syndrome

Childhood Epileptic Aphasia
Benign Familial Neonatal Epilepsy

Familial Neonatal Seizures

Bfns

Benign Familial Neonatal Convulsions

Benign Familial Neonatal Seizures

Epilepsy Benign Neonatal Familial

Familial Benign Neonatal Convulsions

Benign Neonatal Familial Convulsions

Familial Benign Neonatal Epilepsy

Epilepsy, Benign Neonatal, 2

Benign Familial Convulsion
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Psychotic Disorder

Psychotic Disorders

Mental Or Behavioural Disorder

Psychotic

Mental Disorders
Benign Epilepsy With Centrotemporal Spikes

Rolandic Epilepsy

Benign Rolandic Epilepsy

Epilepsy, Rolandic

Bcects

Benign Childhood Epilepsy With Centrotemporal Spike

Sylvan Seizures

Becrs

Bects

Bre

Benign Epilepsy Of Childhood With Centrotemporal Spikes

Benign Familial Epilepsy Of Childhood With Rolandic Spikes

Centrotemporal Epilepsy
Early Infantile Epileptic Encephalopathy

Early Infantile Epileptic Encephalopathy With Burst-Suppression

Early Infantile Epileptic Encephalopathy With Suppression Bursts

Eiee

Early Infantile Epileptic Encephalopathy With Suppression-Bursts

Ohtahara Syndrome

Encephalopathy, Epileptic, Early Infantile
West Syndrome

Infantile Spasms

Infantile Spasms Syndrome

Infantile Spasm

X-Linked Infantile Spasm Syndrome

X-Linked Infantile Spasms

Epileptic Encephalopathy, Early Infantile, 1

Is

Tonic Spasms With Clustering, Arrest Of Psychomotor Development And Hypsarrhythmia On Eeg

West'S Syndrome

Spasms, Infantile

Is -[Infantile Spasm]

Salaam Spasm

Salaam Tic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05805 GRIN2D Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GRIN2D VGNC VGNC:41495
Mus musculus GRIN2D MGD MGI:95823
Rattus norvegicus GRIN2D RGD RGD:2740
Bos taurus GRIN2D VGNC VGNC:29649