Sigmar1 - sigma non-opioid intracellular receptor 1 Gene

Rattus norvegicus

Also known as Oprs1

Gene ID: 29336 | Gene type: protein coding

About Sigmar1

Primary_assembly 5: 56,904,159-56,907,017 reverse strand.mRatBN7.2:CM026978.1

This gene has 2 transcripts (splice variants), 206 orthologues and is associated with 14 phenotypes. Biased expression in Liver (RPKM 836.2), Kidney (RPKM 18.1) and 9 other tissues.

Summary

Enables G protein-coupled Opioid Receptor activity. Involved in nervous system development. Predicted to be located in membrane; nuclear envelope; and postsynaptic density. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 16 and distal spinal muscular atrophy 2. Orthologous to human SIGMAR1 (sigma non-opioid intracellular receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Sigmar1 Products(1)

mRNA	Protein	Name
NM_030996.2	NP_112258.2	sigma non-opioid intracellular receptor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled opioid receptor activity	IDA IDA: Inferred from direct assay	12438547	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	17981125	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in nervous system development	IDA IDA: Inferred from direct assay	12438547	RGD
involved in regulation of postsynapse assembly	IDA IDA: Inferred from direct assay	20018732	RGD
involved in regulation of postsynapse assembly	IMP IMP: Inferred from mutant phenotype	20018732	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	20018732	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	20018732	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sigmar1 Protein Structure

ERG2_Sigma1R

0
100
200
223 a.a.

Protein Preferred Names

Protein Names

sigma non-opioid intracellular receptor 1

opioid receptor, sigma 1	sigma 1-type opioid receptor
sigma1-receptor	sigma1R

Sigmar1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Sigmar1	Q9R0C9	Kcna2	Mus musculus	P63141	Anti Bait CoIP	23332758
Intra	Sigmar1	Q9R0C9	Hspa5	Rattus norvegicus	P06761	Pull Down	17981125

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12908	SIGMAR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12909	Sigmar1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12910	Sigmar1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sigmar1	NCBI	NCBI:10280

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