Hspa5 - heat shock protein family A (Hsp70) member 5 Gene

Rattus norvegicus

Also known as BIP; GRP78; GRP 78

Gene ID: 25617 | Gene type: protein coding

About Hspa5

Primary_assembly 3: 18,055,405-18,059,891 forward strand.mRatBN7.2:CM026976.1

This gene has 1 transcript (splice variant), 257 orthologues, 13 paralogues and is associated with 37 phenotypes. Biased expression in Liver (RPKM 2693.8), Heart (RPKM 215.3) and 9 other tissues.

Summary

Enables misfolded protein binding activity and unfolded protein binding activity. Involved in several processes, including cellular response to cAMP; cellular response to gamma radiation; and cellular response to metal ion. Acts upstream of or within response to endoplasmic reticulum stress. Located in membrane; mitochondrion; and smooth endoplasmic reticulum. Biomarker of fatty liver disease; post-traumatic stress disorder; transient cerebral ischemia; ureteral obstruction; and visual epilepsy. Human ortholog(s) of this gene implicated in dopamine beta-hydroxylase deficiency. Orthologous to human HSPA5 (heat shock protein family A (HSP70) member 5). [provided by Alliance of Genome Resources, Apr 2022]

Hspa5 Products(1)

mRNA	Protein	Name
NM_013083.2	NP_037215.1	endoplasmic reticulum chaperone BiP precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables misfolded protein binding	IDA IDA: Inferred from direct assay	23444373	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	7916014	RGD
enables unfolded protein binding	IPI IPI: Inferred from physical interaction	11884402	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to antibiotic	IEP IEP: Inferred from expression pattern	19332540	RGD
involved in cellular response to cAMP	IEP IEP: Inferred from expression pattern	9058202	RGD
involved in cellular response to calcium ion	IEP IEP: Inferred from expression pattern	9058202	RGD
involved in cellular response to gamma radiation	IEP IEP: Inferred from expression pattern	20470193	RGD
involved in cellular response to manganese ion	IEP IEP: Inferred from expression pattern	23934647	RGD
involved in cellular response to nerve growth factor stimulus	IEP IEP: Inferred from expression pattern	10936191	RGD
involved in cellular response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18757512	RGD
involved in luteolysis	IEP IEP: Inferred from expression pattern	25332219	RGD
involved in neuron apoptotic process	IEP IEP: Inferred from expression pattern	9058202	RGD
involved in neuron differentiation	IEP IEP: Inferred from expression pattern	19322020	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	10936191	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	17849098	RGD
acts upstream of or within response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	23444373	RGD
involved in response to endoplasmic reticulum stress	IEP IEP: Inferred from expression pattern	22189689	RGD
involved in response to methamphetamine hydrochloride	IEP IEP: Inferred from expression pattern	19826936	RGD
involved in stress response to metal ion	IEP IEP: Inferred from expression pattern	17915553	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendritic shaft	IDA IDA: Inferred from direct assay	26088419	RGD
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	19474315	RGD
located in membrane	IDA IDA: Inferred from direct assay	23444373	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	26088419	RGD
located in smooth endoplasmic reticulum	IDA IDA: Inferred from direct assay	22665516	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hspa5 Protein Structure

HSP70

0
200
400
600
654 a.a.

Protein Preferred Names

Protein Names

endoplasmic reticulum chaperone BiP

78 kDa glucose-regulated protein	GRP-78
HSP70 family protein 5	binding-immunoglobulin protein
heat shock 70 kDa protein 5	heat shock 70kD protein 5
heat shock 70kDa protein 5 (glucose-regulated protein)	heat shock protein 5
heat shock protein 70 family protein 5	heat shock protein family A member 5
immunoglobulin heavy chain-binding protein	steroidogenesis-activator polypeptide

Hspa5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Hspa5	P06761	Tg	Rattus norvegicus	P06882	Density Sedimentation	7916014
Intra	Hspa5	P06761	Sigmar1	Rattus norvegicus	Q9R0C9	Pull Down	17981125

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125974	HM03	Inhibitor	99.34%	Unkown
HY-152153	GRP78-IN-3	Inhibitor	99.98%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hspa5	NCBI	NCBI:3309
Mus musculus	Hspa5	NCBI	NCBI:14828

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