P2RX7 - purinergic receptor P2X 7 Gene

Rattus norvegicus

Gene ID: 29665 | Gene type: protein coding

About P2RX7

Primary_assembly 12: 33,879,745-33,934,619 reverse strand.mRatBN7.2:CM026985.1

This gene has 6 transcripts (splice variants), 195 orthologues, 6 paralogues and is associated with 9 phenotypes. Biased expression in Liver (RPKM 74.), Lung (RPKM 67.2) and 9 other tissues.

Summary

Enables several functions, including ATP binding activity; extracellularly ATP-gated cation channel activity; and metal ion binding activity. Involved in several processes, including ATP export; bleb assembly; and positive regulation of macromolecule metabolic process. Located in several cellular components, including bleb; membrane raft; and terminal bouton. Is integral component of nuclear inner membrane. Part of protein-containing complex. Orthologous to human P2RX7 (purinergic receptor P2X 7). [provided by Alliance of Genome Resources, Apr 2022]

P2RX7 Products(1)

mRNA	Protein	Name
NM_019256.2	NP_062129.1	P2X purinoceptor 7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	17394459	RGD
enables channel activity	IDA IDA: Inferred from direct assay	18519738	RGD
enables copper ion binding	IDA IDA: Inferred from direct assay	17394459	RGD
enables extracellularly ATP-gated monoatomic cation channel activity	IDA IDA: Inferred from direct assay	8614837	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	18938136	RGD
enables magnesium ion binding	IDA IDA: Inferred from direct assay	17394459	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	17036048	RGD
enables protein serine/threonine kinase activator activity	IMP IMP: Inferred from mutant phenotype	15023862	RGD
enables purinergic nucleotide receptor activity	IDA IDA: Inferred from direct assay	8614837	RGD
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	19416975	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	17785580	RGD
enables zinc ion binding	IDA IDA: Inferred from direct assay	17394459	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in ATP export	IMP IMP: Inferred from mutant phenotype	31630543	RGD
involved in apoptotic signaling pathway	IDA IDA: Inferred from direct assay	12857854	RGD
involved in bleb assembly	IDA IDA: Inferred from direct assay	12857854	RGD
involved in cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	12857854	RGD
involved in extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	8614837	RGD
involved in membrane depolarization	IDA IDA: Inferred from direct assay	8614837	RGD
involved in neuronal action potential	IDA IDA: Inferred from direct assay	17394459	RGD
involved in pore complex assembly	IDA IDA: Inferred from direct assay	15883745	RGD
involved in pore complex assembly	IMP IMP: Inferred from mutant phenotype	15883745	RGD
involved in positive regulation of cytoskeleton organization	IDA IDA: Inferred from direct assay	12857854	RGD
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	15883745	RGD
involved in positive regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	15883745	RGD
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	15023862	RGD
involved in regulation of presynaptic dense core granule exocytosis	EXP EXP: Inferred from Experiment	24037803	RGD
involved in regulation of presynaptic dense core granule exocytosis	IDA IDA: Inferred from direct assay	24037803	RGD
involved in regulation of sodium ion transport	IDA IDA: Inferred from direct assay	17785580	RGD
involved in response to ATP	IDA IDA: Inferred from direct assay	8614837	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in bleb	IDA IDA: Inferred from direct assay	12857854	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	12857854	RGD
located in nuclear envelope	IDA IDA: Inferred from direct assay	12422208	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	12857854	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	19416975	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	16018975	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2RX7 Protein Structure

P2X_receptor

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619 a.a.

Protein Preferred Names

Protein Names

P2X purinoceptor 7

ATP receptor	P2X purinoceptor 7-like
P2X7 purinoceptor	P2Z receptor
purinergic receptor P2X, ligand-gated ion channel, 7	purinergic receptor P2X7

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09911	P2RX7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09912	P2rx7 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09913	P2RX7 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	P2RX7	NCBI	NCBI:5027

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