Scn8a - sodium voltage-gated channel alpha subunit 8 Gene

Rattus norvegicus

Gene ID: 29710 | Gene type: protein coding

About Scn8a

Primary_assembly 7: 131,982,480-132,151,292 forward strand.mRatBN7.2:CM026980.1

This gene has 3 transcripts (splice variants), 276 orthologues, 26 paralogues and is associated with 30 phenotypes. Biased expression in Brain (RPKM 284.3), Testes (RPKM 17.1) and 2 other tissues.

Summary

Enables sodium ion binding activity and voltage-gated Sodium Channel activity. Involved in nervous system development; neuronal action potential; and sodium ion transport. Located in axon initial segment; node of Ranvier; and plasma membrane. Is integral component of membrane. Part of voltage-gated Sodium Channel complex. Is active in glutamatergic synapse and parallel fiber to Purkinje cell synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic active zone membrane. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in benign familial neonatal epilepsy and developmental and epileptic encephalopathy 13. Orthologous to human SCN8A (sodium voltage-gated channel alpha subunit 8). [provided by Alliance of Genome Resources, Apr 2022]

Scn8a Products(1)

mRNA	Protein	Name
NM_019266.3	NP_062139.2	sodium channel protein type 8 subunit alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15282281	RGD
enables voltage-gated sodium channel activity	IDA IDA: Inferred from direct assay	9603190	RGD
enables voltage-gated sodium channel activity	IMP IMP: Inferred from mutant phenotype	17273863	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in myelination	IEP IEP: Inferred from expression pattern	16652168	RGD
involved in neuronal action potential	IDA IDA: Inferred from direct assay	15917456	RGD
involved in neuronal action potential	IMP IMP: Inferred from mutant phenotype	17273863	RGD
involved in optic nerve development	IEP IEP: Inferred from expression pattern	22473424	RGD
involved in peripheral nervous system development	IEP IEP: Inferred from expression pattern	16652168	RGD
involved in sodium ion transport	IDA IDA: Inferred from direct assay	9603190	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	21118538	RGD
located in axon initial segment	IDA IDA: Inferred from direct assay	11724816	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	10779552	RGD
located in node of Ranvier	IDA IDA: Inferred from direct assay	16652168	RGD
is active in parallel fiber to Purkinje cell synapse	IDA IDA: Inferred from direct assay	10779552	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	10779552	RGD
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	10779552	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Scn8a Protein Structure

Ion_trans

Na_trans_cytopl

Ion_trans

Na_trans_assoc

Ion_trans

Na_channel_gate

Ion_trans

GPHH

0
400
800
1200
1600
1978 a.a.

Protein Preferred Names

Protein Names

sodium channel protein type 8 subunit alpha

Na+ channel	PN4
naCh6	peripheral nerve protein type 4
sodium channel 6	sodium channel protein type VIII subunit alpha
sodium channel, voltage gated, type VIII, alpha subunit	sodium channel, voltage-gated, type 8, alpha polypeptide
sodium channel, voltage-gated, type 8, alpha subunit	sodium channel, voltage-gated, type VIII, alpha polypeptide
voltage-gated sodium channel subunit alpha Nav1.6

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148792	Relutrigine	Inhibitor	99.13%	Unkown
HY-RS12545	SCN8A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12546	Scn8a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12547	Scn8a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Scn8a	NCBI	NCBI:6334

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