Bag3 - BCL2-associated athanogene 3 Gene

Mus musculus

Also known as Bis; mg638

Gene ID: 29810 | Gene type: protein coding

About Bag3

Summary

Predicted to enable adenyl-nucleotide exchange factor activity and chaperone binding activity. Involved in muscle cell cellular homeostasis. Acts upstream of or within several processes, including cellular response to mechanical stimulus; extrinsic apoptotic signaling pathway in absence of ligand; and protein stabilization. Located in Z disc. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Used to study dilated cardiomyopathy 1HH. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1HH and myofibrillar myopathy 6. Orthologous to human BAG3 (BAG cochaperone 3). [provided by Alliance of Genome Resources, Apr 2022]

Bag3 Products(1)

mRNA	Protein	Name
NM_013863.5	NP_038891.4	BAG family molecular chaperone regulator 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11527400	MGI
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	20884878	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to mechanical stimulus	IMP IMP: Inferred from mutant phenotype	16936253	MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand	IDA IDA: Inferred from direct assay	11527400	MGI
involved in muscle cell cellular homeostasis	IMP IMP: Inferred from mutant phenotype	16936253	MGI
acts upstream of or within negative regulation of striated muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	16936253	MGI
acts upstream of or within protein stabilization	IMP IMP: Inferred from mutant phenotype	20884878	MGI
acts upstream of striated muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	16936253	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Z disc	IDA IDA: Inferred from direct assay	16936253	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

BAG family molecular chaperone regulator 3

BAG-3	Bcl-2-binding protein Bis
Bcl-2-interacting death suppressor	bcl-2-associated athanogene 3

Bag3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Bag3	Q9JLV1	EBNA-LP	Epstein-Barr virus	Q8AZK7	Anti Bait CoIP	18457437

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Bag3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71848	BAG-3 Protein, Mouse (P.pastoris, His)	Q9JLV1 (2S-577P)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117282	JG-98		99.88%	Unkown
HY-124611	JG-231	Inhibitor	98.81%	Unkown
HY-156278	FB49	Inhibitor	99.76%	Unkown
HY-RS01344	BAG3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bag3	NCBI	NCBI:9531

Name
Email *

	Sorry, but the email address you supplied was invalid.