HCRTR2 - hypocretin receptor 2 Gene

Homo sapiens

Also known as OX2R; OXR2; ORXR2

Gene ID: 3062 | Gene type: protein coding

About HCRTR2

Cytogenetic location: 6p12.1 Genomic coordinates (GRCh38): 6:55,106,469-55,284,713 (from NCBI)

This gene has 2 transcripts (splice variants), 199 orthologues and 16 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]

HCRTR2 Products(3)

mRNA	Protein	Name
NM_001526.5	NP_001517.2	orexin receptor type 2
NM_001384272.1	NP_001371201.1	orexin receptor type 2
XM_017010798.2	XP_016866287.1	orexin receptor type 2 isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables orexin receptor activity	IDA IDA: Inferred from direct assay	26950369	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in neuropeptide signaling pathway	IDA IDA: Inferred from direct assay	26950369	GOA
involved in regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	26950369	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	26950369	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HCRTR2 Protein Structure

7tm_1

Orexin_rec2

0
100
200
300
400
444 a.a.

Protein Preferred Names

Protein Names

orexin receptor type 2

hypocretin (orexin) receptor 2	hypocretin receptor type 2
orexin type-2 receptor

Related Diseases

Diseases

Alias

Periodic Limb Movement Disorder

Nocturnal Myoclonus Syndrome

Nocturnal Myoclonus

Headache

Headache Disorder

Cluster Headache

Headache, Cluster

Von Economo'S Disease

Encephalitis Lethargica	Von Economo Encephalitis
Von Economo Disease

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
BMIQ11	Obesity Bmiq11
Obesity, Early-Onset	Obesity , Susceptibility To
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Narcolepsy

Paroxysmal Sleep	Gelineau Syndrome
Narcoleptic Syndrome	Narcolepsy-Cataplexy Syndrome
Cataplexy And Narcolepsy	Narcolepsy, Without Cataplexy
Gelineau'S Syndrome	Narcolepsy With Or Without Cataplexy
Narcolepsy Nos

Advanced Sleep Phase Syndrome

Fasps	Familial Advanced Sleep-Phase Syndrome
Advanced Sleep Phase Syndrome, Familial	Familial Advanced Sleep Phase Syndrome
Sleep Phase Syndrome, Advanced, Familial	Advanced Sleep-Phase Syndrome, Familial

Recurrent Hypersomnia

Primary Recurrent Hypersomnia	Hypersomnia Recurrent
Disorders Of Excessive Somnolence	Hypersomnia, Recurrent

Sleep Disorder

Sleep Disorders

Non-Organic Sleep Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06054	HCRTR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06055	Hcrtr2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06056	Hcrtr2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HCRTR2	VGNC	VGNC:73357
Bos taurus	HCRTR2	VGNC	VGNC:29782
Mus musculus	HCRTR2	MGD	MGI:2680765
Felis catus	HCRTR2	VGNC	VGNC:67545
Canis familiaris	HCRTR2	VGNC	VGNC:41624
Rattus norvegicus	HCRTR2	RGD	RGD:2788
Others	HCRTR2	NCBI

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