HLA-DRA - major histocompatibility complex, class II, DR alpha Gene

Homo sapiens

Also known as HLA-DRA1

Gene ID: 3122 | Gene type: protein coding

About HLA-DRA

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,439,887-32,445,046 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 148 orthologues, 13 paralogues and is associated with 1 phenotype. Broad expression in lymph node (RPKM 921.6), lung (RPKM 809.6) and 24 other tissues.

Summary

HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. This molecule is expressed on the surface of various antigen presenting cells such as B lymphocytes, dendritic cells, and monocytes/macrophages, and plays a central role in the immune system and response by presenting Peptides derived from extracellular proteins, in particular, pathogen-derived Peptides to T cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Aug 2020]

HLA-DRA Products(1)

mRNA	Protein	Name
NM_019111.5	NP_061984.2	HLA class II histocompatibility antigen, DR alpha chain precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables T cell receptor binding	IDA IDA: Inferred from direct assay	29884618	GOA
enables peptide antigen binding	IDA IDA: Inferred from direct assay	1448172	GOA
enables polysaccharide binding	IDA IDA: Inferred from direct assay	21502329	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9354468	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antigen processing and presentation of endogenous peptide antigen via MHC class II	IDA IDA: Inferred from direct assay	15322540	GOA
involved in antigen processing and presentation of exogenous peptide antigen via MHC class II	IDA IDA: Inferred from direct assay	15265931	GOA
involved in antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	IDA IDA: Inferred from direct assay	21502329	GOA
involved in cognition	IMP IMP: Inferred from mutant phenotype	23227193	GOA
involved in myeloid dendritic cell antigen processing and presentation	IDA IDA: Inferred from direct assay	29884618	GOA
involved in peptide antigen assembly with MHC class II protein complex	IDA IDA: Inferred from direct assay	1448172	GOA
involved in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IDA IDA: Inferred from direct assay	28467828	GOA
involved in positive regulation of CD4-positive, alpha-beta T cell activation	IDA IDA: Inferred from direct assay	15265931	GOA
involved in positive regulation of T cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	29884618	GOA
involved in positive regulation of memory T cell differentiation	IDA IDA: Inferred from direct assay	27591323	GOA
involved in regulation of T-helper cell differentiation	IDA IDA: Inferred from direct assay	15322540	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of MHC class II protein complex	IDA IDA: Inferred from direct assay	1448172	GOA
part of MHC class II protein complex	IMP IMP: Inferred from mutant phenotype	9354468	GOA
located in cell surface	IDA IDA: Inferred from direct assay	21502329	GOA
located in immunological synapse	IDA IDA: Inferred from direct assay	15322540	GOA
located in late endosome membrane	IDA IDA: Inferred from direct assay	9075930	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	9075930	GOA
located in lysosome	IDA IDA: Inferred from direct assay	8890155	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	8890155	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HLA-DRA Protein Structure

MHC_II_alpha

C1-set

0
100
200
229 a.a.

Protein Preferred Names

Protein Names

HLA class II histocompatibility antigen, DR alpha chain

MHC class II antigen DRA

Related Diseases

Diseases

Alias

Graham-Little-Piccardi-Lassueur Syndrome

Graham Little Syndrome	Graham Little-Piccardi-Lassueur Syndrome
Piccardi-Lassueur-Little Syndrome	Lichen Planus Follicularis

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

Gallbladder Melanoma

Malignant Melanoma Of Gallbladder

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma	Chromophobe Carcinoma Of Kidney
Kidney Chromophobe	Renal Cell Carcinoma, Chromophobe Cell
Crcc	Chrcc
Chromophobe Renal Cell Adenocarcinoma	Chromophobe Renal Carcinoma
Chromophobe Carcinoma

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06210	HLA-DRA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HLA-DRA	MGD	MGI:95900
Rattus norvegicus	HLA-DRA	RGD	RGD:1593283

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