HNF4G - hepatocyte nuclear factor 4 gamma Gene

Homo sapiens

Also known as NR2A2; NR2A3

Gene ID: 3174 | Gene type: protein coding

About HNF4G

Cytogenetic location: 8q21.13 Genomic coordinates (GRCh38): 8:75,407,649-75,566,834 (from NCBI)

This gene has 5 transcripts (splice variants), 240 orthologues and 11 paralogues. Biased expression in small intestine (RPKM 55.0), duodenum (RPKM 46.4) and 5 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in several cellular components, including intercellular bridge; mitotic spindle; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

HNF4G Products(2)

mRNA	Protein	Name
NM_001330561.2	NP_001317490.1	hepatocyte nuclear factor 4-gamma isoform 2
NM_004133.5	NP_004124.5	hepatocyte nuclear factor 4-gamma isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	23896584	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12220531	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23896584	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HNF4G Protein Structure

zf-C4

Hormone_recep

0
100
200
300
408 a.a.

Protein Preferred Names

Protein Names

hepatocyte nuclear factor 4-gamma

HNF-4-gamma

Related Diseases

Diseases

Alias

Maturity-Onset Diabetes Of The Young, Type 1

Maturity-Onset Diabetes Of The Young Type 1	MODY1
Mild Juvenile Diabetes Mellitus	Mody, Type I
Diabetes Mellitus Type 2	Mody Type 1
Mody, Type 1	Maturity-Onset Diabetes Of The Young 1
Mody-1	Diabetes Of The Young, Maturity-Onset, Type 1

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06258	HNF4G Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HNF4G	VGNC	VGNC:29892
Mus musculus	HNF4G	MGD	MGI:1353604
Rattus norvegicus	HNF4G	RGD	RGD:1310102
Macaca mulatta	HNF4G	VGNC	VGNC:73493
Felis catus	HNF4G	VGNC	VGNC:67604
Canis familiaris	HNF4G	VGNC	VGNC:41726

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