ENPP7 - ectonucleotide pyrophosphatase/phosphodiesterase 7 Gene

Homo sapiens

Also known as NPP7; NPP-7; E-NPP 7; ALK-SMase

Gene ID: 339221 | Gene type: protein coding

About ENPP7

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:79,730,943-79,742,219 (from NCBI)

This gene has 2 transcripts (splice variants), 273 orthologues and 6 paralogues. Biased expression in small intestine (RPKM 36.1), duodenum (RPKM 15.1) and 1 other tissue.

Summary

The protein encoded by this gene is an intestinal alkaline sphingomyelin phosphodiesterase that converts sphingomyelin to ceramide and phosphocholine. The encoded protein is anchored in the cell membrane, and it may function to protect the intestinal mucosa from inflammation and tumorigenesis. This protein is glycosylated and also exhibits lysophosphatidylcholine hydrolase activity. [provided by RefSeq, Oct 2016]

ENPP7 Products(1)

mRNA	Protein	Name
NM_178543.5	NP_848638.3	ectonucleotide pyrophosphatase/phosphodiesterase family member 7 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphoric diester hydrolase activity	IDA IDA: Inferred from direct assay	16255717	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables sphingomyelin phosphodiesterase activity	IDA IDA: Inferred from direct assay	12671034	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	28292932	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA replication	IDA IDA: Inferred from direct assay	12671034	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	12671034	GOA
involved in sphingomyelin metabolic process	IDA IDA: Inferred from direct assay	12671034	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	12671034	GOA
located in microvillus	IDA IDA: Inferred from direct assay	12671034	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15205117	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENPP7 Protein Structure

Phosphodiest

0
100
200
300
400
458 a.a.

Protein Preferred Names

Protein Names

ectonucleotide pyrophosphatase/phosphodiesterase family member 7

alkaline sphingomyelin phosphodiesterase

Recombinant ENPP7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77358	ENPP-7 Protein, Human (HEK293, His)	Q6UWV6 (A22-S439)	≥95%

Related Diseases

Diseases

Alias

Familial Adenomatous Polyposis

Adenomatous Polyposis Coli	Fap
Familial Polyposis Coli	Familial Multiple Polyposis Syndrome
Adenomatous Polyposis Of The Colon	Familial Intestinal Polyposis
Fpc	Familial Adenomatous Polyposis Of The Colon
Familial Multiple Polyposis	Familial Polyposis Of The Colon
Hereditary Polyposis Coli	Polyposis, Adenomatous Intestinal
Adenomatous Familial Polyposis	Adenomatous Familial Polyposis Syndrome
Myh-Associated Polyposis	Colorectal Adenomatous Polyposis
Adenomatous Polyposis, Familial	Mutyh-Associate Polyposis

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04393	ENPP7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ENPP7	VGNC	VGNC:82476
Bos taurus	ENPP7	VGNC	VGNC:55820
Mus musculus	ENPP7	MGD	MGI:3027917
Canis familiaris	ENPP7	VGNC	VGNC:40378
Rattus norvegicus	ENPP7	RGD	RGD:1359324
Macaca mulatta	ENPP7	VGNC	VGNC:72090

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