TMPRSS11A - transmembrane serine protease 11A Gene

Homo sapiens

Also known as HESP; ECRG1; HATL1

Gene ID: 339967 | Gene type: protein coding

About TMPRSS11A

Cytogenetic location: 4q13.2 Genomic coordinates (GRCh38): 4:67,909,395-67,963,493 (from NCBI)

This gene has 3 transcripts (splice variants), 534 orthologues and 17 paralogues. Restricted expression toward esophagus (RPKM 55.7).

Summary

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMPRSS11A Products(2)

mRNA	Protein	Name
NM_001114387.2	NP_001107859.1	transmembrane protease serine 11A isoform 2
NM_182606.4	NP_872412.3	transmembrane protease serine 11A isoform 1

Protein Preferred Names

Protein Names

transmembrane protease serine 11A

airway trypsin-like protease 1

Related Diseases

Diseases

Alias

Iron-Refractory Iron Deficiency Anemia

IRIDA	Anemia, Hypochromic Microcytic, With Defect In Iron Metabolism
Iron-Handling Disorder, Hereditary	Pseudo-Iron-Deficiency Anemia
Irida Syndrome	Hereditary Iron-Handling Disorder
Hypochromic Microcytic Anemia With Defect In Iron Metabolism	Anemia, Iron Deficiency, Iron-Refractory

Esophageal Cancer

Esophageal Carcinoma	Carcinoma Of Esophagus
Esophageal Squamous Cell Carcinoma, Somatic	Esophageal Carcinoma, Somatic
Esophagus Cancer	Gastric Cardia Adenocarcinoma
Esophageal Neoplasms	Esophageal Cancer, Somatic
Cancer Of Esophagus	Cancer Of Oesophagus
Carcinoma Of Oesophagus	Ca Lower Third Oesophagus
Ca Middle Third Oesophagus	Malignant Neoplasm Of Distal Third Of Esophagus
Malignant Neoplasm Of Lower Third Of Oesophagus	Malignant Neoplasm Of Middle Third Of Oesophagus
Malignant Neoplasm Of Proximal Third Of Esophagus	Malignant Neoplasm Of Upper Third Esophagus
Malignant Tumor Of Abdominal Esophagus	Malignant Tumor Of Distal Third Of Esophagus
Malignant Tumor Of Proximal Third Of Esophagus	Malignant Tumor Of The Middle Third Of The Esophagus
ESCR	Aerodigestive Tract Cancer
Escc	Esophageal Squamous Cell Carcinoma
Cancer, Esophageal	Malignant Neoplasm Of Esophagus
Squamous Cell Carcinoma Of Esophagus	Malignant Neoplasm Of Middle Third Of Esophagus

Ichthyosis

Ichthyoses	Non-Syndromic Ichthyosis
Congenital Ichthyosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14763	TMPRSS11A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TMPRSS11A	VGNC	VGNC:47628
Rattus norvegicus	TMPRSS11A	RGD	RGD:1596322
Macaca mulatta	TMPRSS11A	VGNC	VGNC:79673
Bos taurus	TMPRSS11A	VGNC	VGNC:55081
Felis catus	TMPRSS11A	VGNC	VGNC:66381
Mus musculus	TMPRSS11A	MGD	MGI:2684853

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