HMX3 - H6 family homeobox 3 Gene

Homo sapiens

Also known as NKX5.1; Nkx5-1; NKX-5.1

Gene ID: 340784 | Gene type: protein coding

About HMX3

Cytogenetic location: 10q26.13 Genomic coordinates (GRCh38): 10:123,135,970-123,139,423 (from NCBI)

This gene has 1 transcript (splice variant), 256 orthologues and 3 paralogues. Low expression observed in reference dataset.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in ear development and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including embryo implantation; maternal process involved in female pregnancy; and neuromuscular process controlling balance. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

HMX3 Products(1)

mRNA	Protein	Name
NM_001105574.2	NP_001099044.1	homeobox protein HMX3

HMX3 Protein Structure

Homeobox

0
100
200
300
357 a.a.

Protein Preferred Names

Protein Names

homeobox protein HMX3

homeo box (H6 family) 3

Related Diseases

Diseases

Alias

Oculoauricular Syndrome

OCACS	Schorderet-Munier-Franceschetti Syndrome
Microphthalmia, Microcornea, Anterior Segment Dysgenesis, Cataract, Ocular Coloboma, Retinal Pigment Epithelium Abnormalities, Rod-Cone Dystrophy, And Anomalies Of The External Ear	Oculoauricular Syndrome, Schorderet Type
Oculo-Auricular Syndrome

Deafness, Autosomal Recessive 17

DFNB17	Autosomal Recessive Nonsyndromic Deafness 17
Autosomal Recessive Deafness 17

Superior Semicircular Canal Dehiscence

Superior Canal Dehiscence Syndrome	Superior Semicircular Canal Dehiscence Syndrome
Canal Dehiscence Syndrome	Superior Canal Dehiscence
Superior Canal Syndrome	Third Mobile Window Syndrome
Scds	Anemia, Sickle Cell

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06254	HMX3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	HMX3	VGNC	VGNC:49908
Bos taurus	HMX3	VGNC	VGNC:50191
Mus musculus	HMX3	MGD	MGI:107160
Macaca mulatta	HMX3	VGNC	VGNC:73491
Rattus norvegicus	HMX3	RGD	RGD:1559927

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