OR2AT4 - olfactory receptor family 2 subfamily AT member 4 Gene

Homo sapiens

Also known as OR11-265

Gene ID: 341152 | Gene type: protein coding

About OR2AT4

This gene has 5 transcripts (splice variants), 63 orthologues and 130 paralogues. Low expression observed in reference dataset.

Summary

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory Receptor Proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of Other organisms. [provided by RefSeq, Jul 2008]

OR2AT4 Products(2)

mRNA	Protein	Name
NM_001005285.2	NP_001005285.1	olfactory receptor 2AT4 isoform 1
NM_001405852.1	NP_001392781.1	olfactory receptor 2AT4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables olfactory receptor activity	IDA IDA: Inferred from direct assay	24999593	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	24999593	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	24999593	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OR2AT4 Protein Structure

7tm_1

0
100
200
300
320 a.a.

Protein Preferred Names

Protein Names

olfactory receptor 2AT4

olfactory receptor OR11-265 pseudogene

Related Diseases

Diseases

Alias

Telogen Effluvium

Diffuse Alopecia Areata

Diffuse Alopecia

Lymph Node Carcinoma

Lymph Node Cancer	Lymph Node Neoplasm
Neoplasm Of Lymph Node

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139783	3-Campholenyl-2-butanol	Inhibitor	≥98.0%	Unkown
HY-RS09812	OR2AT4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	OR2AT4	RGD	RGD:1333428
Mus musculus	OR2AT4	MGD	MGI:3030354

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