2. Gene
  3. MACC1 - MET transcriptional regulator MACC1 Gene

MACC1 - MET transcriptional regulator MACC1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as 7A5; SH3BP4L

Gene ID: 346389 | Gene type: protein coding

About MACC1

Cytogenetic location: 7p21.1 Genomic coordinates (GRCh38): 7:20,134,655-20,217,384 (from NCBI)

This gene has 5 transcripts (splice variants), 204 orthologues, 1 paralogue and is associated with 77 phenotypes. Broad expression in small intestine (RPKM 6.2), duodenum (RPKM 5.1) and 17 other tissues.

Summary

MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon Cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009]

MACC1 Products(1)

mRNA Protein Name
NM_182762.4 NP_877439.3 metastasis-associated in colon cancer protein 1
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19098908 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MACC1 Protein Structure

SH3_2

SH3_2: Variant SH3 domain (553 - 617)

  • 0
  • 200
  • 400
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  • 800
  • 852 a.a.
Protein Preferred Names Protein Names

metastasis-associated in colon cancer protein 1

MACC1, MET transcriptional regulator

Related Diseases

Diseases Alias
Renal Pelvis Carcinoma

Malignant Neoplasm Of Renal Pelvis

Malignant Tumor Of Renal Pelvis

Carcinoma Of Kidney Pelvis

Malignant Renal Pelvis Neoplasm

Renal Pelvis Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07941 MACC1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MACC1 VGNC VGNC:53651
Canis familiaris MACC1 VGNC VGNC:42913
Mus musculus MACC1 MGD MGI:2685113
Felis catus MACC1 VGNC VGNC:63358
Macaca mulatta MACC1 VGNC VGNC:74404
Rattus norvegicus MACC1 RGD RGD:1309838