IL10RB - interleukin 10 receptor subunit beta Gene

Homo sapiens

Also known as CRFB4; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2; IL-10RB

Gene ID: 3588 | Gene type: protein coding

About IL10RB

Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:33,266,367-33,297,221 (from NCBI)

This gene has 9 transcripts (splice variants), 210 orthologues, 11 paralogues and is associated with 3 phenotypes. Ubiquitous expression in placenta (RPKM 32.9), colon (RPKM 23.4) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three Other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]

IL10RB Products(4)

mRNA	Protein	Name
NM_000628.5	NP_000619.3	interleukin-10 receptor subunit beta isoform 1 precursor
NM_001405849.1	NP_001392778.1	interleukin-10 receptor subunit beta isoform 2 precursor
NM_001405850.1	NP_001392779.1	interleukin-10 receptor subunit beta isoform 3 precursor
NM_001406840.1	NP_001393769.1	interleukin-10 receptor subunit beta isoform 4 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables coreceptor activity	IDA IDA: Inferred from direct assay	16982608	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12483210	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in interleukin-10-mediated signaling pathway	IDA IDA: Inferred from direct assay	16982608	GOA
involved in positive regulation of cellular respiration	IMP IMP: Inferred from mutant phenotype	25930096	GOA
involved in positive regulation of receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	16982608	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL10RB Protein Structure

Tissue_fac

Interfer-bind

0
100
200
300
325 a.a.

Protein Preferred Names

Protein Names

interleukin-10 receptor subunit beta

IL-10 receptor subunit beta

IL10RB Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IL10RB	Q08334	IL22RA1	Homo sapiens	Q8N6P7	ELISA	15120653

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL10RB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72599	IL-10R beta Protein, Human (HEK293, His)	Q08334/NP_000619.3 (M20-S220)	≥95%
HY-P74839	IL-10R beta Protein, Human (HEK293, His-hFc)	Q08334 (M20-S220)	≥95%

Related Diseases

Diseases

Alias

Inflammatory Bowel Disease 25, Autosomal Recessive

Immune Dysregulation-Inflammatory Bowel Disease-Arthritis-Recurrent Infections Syndrome	IBD25
Inflammatory Bowel Disease 25, Early Onset, Autosomal Recessive	Il10-Related Early-Onset Ibd
Il10-Related Early-Onset Inflammatory Bowel Disease	Inflammatory Bowel Disease, Early-Onset, Autosomal Recessive
Autosomal Recessive Early-Onset Inflammatory Bowel Disease	Autosomal Recessive Early-Onset Ibd
Early-Onset Autosomal Recessive Inflammatory Bowel Disease	Bowel Disease, Inflammatory, Type 25, Autosomal Recessive

Inflammatory Bowel Disease 25

Early Onset Autosomal Recessive Inflammatory Bowel Disease 25	Ibd25
Inflammatory Bowel Disease 25, Autosomal Recessive

Hepatitis B

Chronic Hepatitis B	Hepatitis B Infection
Serum Hepatitis	HBV
Hepatitis B Chronic	Hbv, Susceptibility To
Hepatitis B, Chronic	Chronic Hepatitis B Without Delta Agent
Chronic Hbv - [Hepatitis B Virus] Infection	Hepatitis B Nos
Chronic Type B Viral Hepatitis	Hep B Nos

Colitis

Ulcerative Colitis

Colitis Gravis	Left Sided Ulcerative Colitis
Left-Sided Ulcerative Colitis	Idiopathic Proctocolitis
Inflammatory Bowel Disease, Ulcerative Colitis Type	Uc
Colitis Ulcerative	Colitis, Ulcerative
Chronic Left-Sided Ulcerative Colitis	Uc - [Ulcerative Colitis]
Chronic Ulcerative Enteritis	Mucosal Proctocolitis
Ulcerative Mucosal Proctocolitis	Left Hemicolitis

Erythematosquamous Dermatosis

Other Erythematosquamous Dermatosis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Rubella

German Measles	Three Day Measles
Rubella Nos

Immunodeficiency 28

IMD28	Ifngr2 Deficiency
Immunodeficiency 28, Mycobacteriosis, Autosomal Recessive	Immunodeficiency 28, Mycobacteriosis
Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar2 Deficiency	Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 2 Deficiency
Msmd Due To Complete Ifngammar2 Deficiency	Msmd Due To Complete Interferon Gamma Receptor 2 Deficiency
Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar2 Deficiency	Autosomal Recessive Msmd Due To Partial Ifngammar2 Deficiency
Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 2 Deficiency	Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 2 Deficiency
Immunodeficiency, Type 28, Mycobacteriosis

Folliculitis

Narcolepsy

Paroxysmal Sleep	Gelineau Syndrome
Narcoleptic Syndrome	Narcolepsy-Cataplexy Syndrome
Cataplexy And Narcolepsy	Narcolepsy, Without Cataplexy
Gelineau'S Syndrome	Narcolepsy With Or Without Cataplexy
Narcolepsy Nos

Immunodeficiency 35

Tyrosine Kinase 2 Deficiency	IMD35
Tyk2 Deficiency	Autosomal Recessive Hyper-Ige Syndrome With Atypical Mycobacteriosis
Susceptibility To Infection Due To Tyk2 Deficiency	Hyper-Ige Syndrome With Atypical Mycobacteriosis, Autosomal Recessive
Hies With Atypical Mycobacteriosis, Autosomal Recessive	Autosomal Recessiv Hies With Atypical Mycobacteriosis
Autosomal Recessive Hyper-Ige Syndrome Due To Tyk2 Deficiency	Autosomal Recessive Hies With Atypical Mycobacteriosis

Acute Necrotizing Encephalitis

Acute Necrotizing Encephalopathy	Postinfectious Acute Necrotizing Hemorrhagic Encephalopathy
Ane	Acute Necrotizing Encephalopathy Type 1
Adane	Ane1
Autosomal Dominant Acute Necrotizing Encephalopathy	Iiae3
Susceptibility To Acute Necrotizing Encephalopathy	Susceptibility To Infection-Induced Acute Encephalopathy
Encephalopathy, Acute Necrotizing, Susceptibility To	Encephalitis, Acute Necrotizing

Gastrointestinal Defects And Immunodeficiency Syndrome 1

Familial Intestinal Polyatresia Syndrome	Fipa
Gastrointestinal Defects And Immunodeficiency Syndrome	Multiple Gastrointestinal Atresias
Familial Isolated Pituitary Adenoma	Intestinal Atresia, Multiple
Multiple Intestinal Atresia	GIDID1
Multiple Intestinal Atresia And/Or Inflammatory Bowel Disease With Or Without Immunodeficiency	Minat
Gidid	Meddra:10028210
Familial Isolated Pituitary Adenoma Syndrome	Intestinal Atresia Multiple
Combined Immunodeficiency-Enteropathy Spectrum	Cid-Mia/Early-Onset Ibd
Intestinal Atresia, Multiple And/Or Inflammatory Bowel Disease With Or Without Immunodeficiency	Mia
Gastrointestinal Defect And Immunodeficiency Syndrome	Pituitary Adenoma Predisposition
Pituitary Adenoma, Familial Isolated

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06674	IL10RB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990776	Vimekofusp		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IL10RB	RGD	RGD:1560373
Bos taurus	IL10RB	VGNC	VGNC:56219
Felis catus	IL10RB	VGNC	VGNC:97463
Mus musculus	IL10RB	MGD	MGI:109380

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