Postn - periostin Gene

Rattus norvegicus

Also known as Plf

Gene ID: 361945 | Gene type: protein coding

About Postn

Summary

Predicted to enable cell adhesion molecule binding activity; heparin binding activity; and metal ion binding activity. Involved in several processes, including bone regeneration; cellular response to growth factor stimulus; and negative regulation of cell-substrate adhesion. Located in cytoplasm; extracellular space; and neuromuscular junction. Used to study congestive heart failure. Biomarker of artery disease (multiple); degenerative disc disease; end stage renal disease; periodontitis; and tendinitis. Orthologous to human POSTN (periostin). [provided by Alliance of Genome Resources, Apr 2022]

Postn Products(1)

mRNA	Protein	Name
NM_001108550.1	NP_001102020.1	periostin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19478074	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in bone regeneration	IEP IEP: Inferred from expression pattern	17878602	RGD
involved in cellular response to fibroblast growth factor stimulus	IEP IEP: Inferred from expression pattern	16325820	RGD
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	22886209	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	20458732	RGD
involved in negative regulation of cell-matrix adhesion	IDA IDA: Inferred from direct assay	15381649	RGD
involved in negative regulation of substrate adhesion-dependent cell spreading	IDA IDA: Inferred from direct assay	15381649	RGD
involved in neuron projection extension	IMP IMP: Inferred from mutant phenotype	24523534	RGD
involved in positive regulation of chemokine (C-X-C motif) ligand 2 production	IMP IMP: Inferred from mutant phenotype	24260297	RGD
involved in positive regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	16325820	RGD
involved in regulation of systemic arterial blood pressure	IDA IDA: Inferred from direct assay	15381649	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	18270434	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	15121739	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	23453657	RGD
involved in response to muscle activity	IEP IEP: Inferred from expression pattern	19620321	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	19006175	RGD
located in neuromuscular junction	IDA IDA: Inferred from direct assay	19620321	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

periostin

periostin, osteoblast specific factor

periostin-like factor

Recombinant Postn Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79348	Periostin/OSF-2 Protein, Rat (HEK293, His)	D3ZAF5 (N24-S800)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10884	POSTN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Postn	NCBI	NCBI:10631
Mus musculus	Postn	NCBI	NCBI:50706

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