INPP1 - inositol polyphosphate-1-phosphatase Gene

Homo sapiens

Gene ID: 3628 | Gene type: protein coding

About INPP1

Cytogenetic location: 2q32.2 Genomic coordinates (GRCh38): 2:190,343,589-190,371,665 (from NCBI)

This gene has 15 transcripts (splice variants), 209 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 21.9), esophagus (RPKM 18.0) and 24 other tissues.

Summary

This gene encodes the Enzyme inositol polyphosphate-1-phosphatase, one of the Enzymes involved in phosphatidylinositol signaling pathways. This Enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate. [provided by RefSeq, Jul 2008]

INPP1 Products(2)

mRNA	Protein	Name
NM_001128928.2	NP_001122400.1	inositol polyphosphate 1-phosphatase
NM_002194.4	NP_002185.1	inositol polyphosphate 1-phosphatase

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	26871637	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INPP1 Protein Structure

Inositol_P

0
100
200
300
399 a.a.

Protein Preferred Names

Protein Names

inositol polyphosphate 1-phosphatase

IPP

INPP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	INPP1	P49441	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	26871637
Intra	INPP1	P49441	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	26871637
Intra	INPP1	P49441	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	26871637

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant INPP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70361	INPP1 Protein, Human (HEK293, His)	P49441 (M1-T399)	≥95%

Related Diseases

Diseases

Alias

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Ring Dermoid Of Cornea

RDC	Ring Dermoid Syndrome
Bilateral, Annular Limbal Dermoids With Corneal And Conjunctival Extension	Dermoid Of Cornea, Ring

Cone-Rod Dystrophy 5

CORD5

Dystrophy, Cone-Rod, Type 5

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-151374	3-IN-PP1	Inhibitor	99.58%	Unkown
HY-RS06824	INPP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	INPP1	VGNC	VGNC:42027
Rattus norvegicus	INPP1	RGD	RGD:1306071
Bos taurus	INPP1	VGNC	VGNC:30208
Macaca mulatta	INPP1	VGNC	VGNC:73746
Felis catus	INPP1	VGNC	VGNC:107567
Mus musculus	INPP1	MGD	MGI:104848
Others	INPP1	NCBI

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