2. Gene
  3. Yap1 - Yes1 associated transcriptional regulator Gene

Yap1 - Yes1 associated transcriptional regulator Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Yap; YAP65

Gene ID: 363014 | Gene type: protein coding

About Yap1

Primary_assembly 8: 5,095,722-5,167,010 reverse strand.mRatBN7.2:CM026981.1

This gene has 5 transcripts (splice variants), 219 orthologues, 1 paralogue and is associated with 22 phenotypes. Biased expression in Heart (RPKM 265.7), Lung (RPKM 223.8) and 9 other tissues.

Summary

Predicted to enable several functions, including proline-rich region binding activity; protein C-terminus binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including positive regulation of cell population proliferation; regulation of gene expression; and response to steroid hormone. Predicted to act upstream of or within several processes, including animal organ development; regulation of epithelial cell differentiation; and regulation of signal transduction. Predicted to be located in cytosol; female germ cell nucleus; and membrane. Predicted to be part of TEAD-YAP complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in uveal coloboma-cleft lip and palate-intellectual disability. Orthologous to human YAP1 (Yes1 associated transcriptional regulator). [provided by Alliance of Genome Resources, Apr 2022]

Yap1 Products(2)

mRNA Protein Name
NM_001394329.1 NP_001381258.1 transcriptional coactivator YAP1 2
NM_001394328.1 NP_001381257.1 transcriptional coactivator YAP1 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
31298560 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Yap1 Protein Structure

WW

WW: cd00201 (155 - 184)

WW

WW: smart00456 (212 - 244)

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  • 491 a.a.
Protein Preferred Names Protein Names

transcriptional coactivator YAP1

65 kDa Yes-associated protein

protein yorkie homolog

yes-associated protein 1

yes-associated protein YAP65 homolog

yorkie homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N6682 Cytochalasin D Inhibitor 99.79% Unkown
HY-138565 K-975 Inhibitor 99.64% Unkown
HY-125269 TED-347 Inhibitor 98.97% Unkown
HY-161573 BAY-593 Inhibitor 99.94% Unkown
HY-RS15911 YAP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-163622 USP10-IN-3 Inducer 98.00% Unkown
HY-RS15912 Yap1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-156024 TEAD-IN-6 Modulator / Unkown
HY-161573A (7S)-BAY-593 Inhibitor 99.61% Unkown
HY-E70293 N-Acetylgalactosaminyltransferase 12 / Unkown
HY-RS15913 Yap1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-161573B BAY-593 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Yap1 NCBI NCBI:10413