Map3k5 - mitogen-activated protein kinase kinase kinase 5 Gene

Rattus norvegicus

Also known as Ask1; RGD1306565

Gene ID: 365057 | Gene type: protein coding

About Map3k5

Primary_assembly 1: 14,685,492-14,904,800 forward strand.mRatBN7.2:CM026974.1

This gene has 4 transcripts (splice variants), 206 orthologues, 2 paralogues and is associated with 29 phenotypes. Biased expression in Adrenal (RPKM 13.), Kidney (RPKM 13.) and 9 other tissues.

Summary

Enables MAP kinase kinase kinase activity. Involved in several processes, including endothelial cell apoptotic process; positive regulation of MAPK cascade; and positive regulation of cardiac muscle cell apoptotic process. Located in cytosol and external side of plasma membrane. Used to study cerebral infarction and myocardial infarction. Biomarker of membranous glomerulonephritis; transient cerebral ischemia; and visual epilepsy. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human MAP3K5 (mitogen-activated protein kinase kinase kinase 5). [provided by Alliance of Genome Resources, Apr 2022]

Map3k5 Products(1)

mRNA	Protein	Name
NM_001277694.1	NP_001264623.1	mitogen-activated protein kinase kinase kinase 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables MAP kinase kinase kinase activity	IDA IDA: Inferred from direct assay	20550965	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12050113	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in JNK cascade	IDA IDA: Inferred from direct assay	12524169	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	16157298	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	20716917	RGD
involved in endothelial cell apoptotic process	IEP IEP: Inferred from expression pattern	17932313	RGD
involved in positive regulation of JUN kinase activity	IMP IMP: Inferred from mutant phenotype	20716917	RGD
involved in positive regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	22635076	RGD
involved in positive regulation of p38MAPK cascade	IMP IMP: Inferred from mutant phenotype	20716917	RGD
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	20550965	RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	14638553	RGD
involved in response to endoplasmic reticulum stress	IEP IEP: Inferred from expression pattern	12050113	RGD
involved in response to ischemia	IEP IEP: Inferred from expression pattern	20550965	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	12786973	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Map3k5 Protein Structure

DUF4071

ASK_PH

STKc_ASK

0
300
600
900
1200
1381 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase kinase kinase 5

apoptosis signal regulating kinase 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08058	MAP3K5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08059	Map3k5 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08060	Map3k5 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Map3k5	NCBI	NCBI:4217

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