ITIH3 - inter-alpha-trypsin inhibitor heavy chain 3 Gene

Homo sapiens

Also known as H3P; SHAP; ITI-HC3

Gene ID: 3699 | Gene type: protein coding

About ITIH3

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:52,794,796-52,808,797 (from NCBI)

This gene has 11 transcripts (splice variants), 299 orthologues and 11 paralogues. Restricted expression toward liver (RPKM 228.8).

Summary

This gene encodes the heavy chain subunit of the pre-alpha-trypsin inhibitor complex. This complex may stabilize the extracellular matrix through its ability to bind hyaluronic acid. Polymorphisms of this gene may be associated with increased risk for schizophrenia and major depressive disorder. This gene is present in an inter-alpha-trypsin inhibitor family gene cluster on chromosome 3. [provided by RefSeq, Jul 2015]

ITIH3 Products(10)

mRNA	Protein	Name
NM_001392019.1	NP_001378948.1	inter-alpha-trypsin inhibitor heavy chain H3 isoform 1 precursor
NM_001392020.1	NP_001378949.1	inter-alpha-trypsin inhibitor heavy chain H3 isoform 2 precursor
NM_001392021.1	NP_001378950.1	inter-alpha-trypsin inhibitor heavy chain H3 isoform 3 precursor
NM_001392022.1	NP_001378951.1	inter-alpha-trypsin inhibitor heavy chain H3 isoform 5 precursor
NM_001392023.1	NP_001378952.1	inter-alpha-trypsin inhibitor heavy chain H3 isoform 6 precursor
NM_001392024.1	NP_001378953.1	inter-alpha-trypsin inhibitor heavy chain H3 isoform 7 precursor
NM_001392025.1	NP_001378954.1	inter-alpha-trypsin inhibitor heavy chain H3 isoform 8 precursor
NM_001392026.1	NP_001378955.1	inter-alpha-trypsin inhibitor heavy chain H3 isoform 9 precursor
NM_001392027.1	NP_001378956.1	inter-alpha-trypsin inhibitor heavy chain H3 isoform 10 precursor
NM_002217.4	NP_002208.3	inter-alpha-trypsin inhibitor heavy chain H3 isoform 4 preproprotein

ITIH3 Protein Structure

VIT

VWA

ITI_HC_C

0
200
400
600
800
890 a.a.

Protein Preferred Names

Protein Names

inter-alpha-trypsin inhibitor heavy chain H3

ITI heavy chain H3

Recombinant ITIH3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70407	ITIH3 Protein, Human (HEK293, His)	Q06033-1 (L35-D651)	≥95%

Related Diseases

Diseases

Alias

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Immunoglobulin Heavy-And-Light Chain

Ah/Al Amyloidosis

Ig Heavy-And-Light-Chain Amyloidosis

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06976	ITIH3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ITIH3	MGD	MGI:96620
Macaca mulatta	ITIH3	VGNC	VGNC:73795
Felis catus	ITIH3	VGNC	VGNC:67861
Rattus norvegicus	ITIH3	RGD	RGD:620633
Bos taurus	ITIH3	VGNC	VGNC:30335
Canis familiaris	ITIH3	VGNC	VGNC:103686
Others	ITIH3	NCBI

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