SLC27A1 - solute carrier family 27 member 1 Gene

Homo sapiens

Also known as FATP; FATP1; ACSVL5; FATP-1

Gene ID: 376497 | Gene type: protein coding

About SLC27A1

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:17,468,767-17,506,168 (from NCBI)

This gene has 9 transcripts (splice variants), 279 orthologues and 12 paralogues. Ubiquitous expression in ovary (RPKM 10.2), fat (RPKM 9.1) and 24 other tissues.

Summary

Enables biotin transmembrane transporter activity; efflux transmembrane transporter activity; and long-chain fatty acid transporter activity. Involved in several processes, including carboxylic acid transmembrane transport; glycerophospholipid biosynthetic process; and lipid transport across blood-brain barrier. Located in membrane. Part of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC27A1 Products(1)

mRNA	Protein	Name
NM_198580.3	NP_940982.1	long-chain fatty acid transport protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables biotin transmembrane transporter activity	IDA IDA: Inferred from direct assay	28035674	GOA
enables efflux transmembrane transporter activity	IDA IDA: Inferred from direct assay	28035674	GOA
enables efflux transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	31091338	GOA
enables long-chain fatty acid transmembrane transporter activity	IDA IDA: Inferred from direct assay	28035674	GOA
enables long-chain fatty acid transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	21395585	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28178239	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in biotin import across plasma membrane	IDA IDA: Inferred from direct assay	28035674	GOA
involved in biotin transport	IDA IDA: Inferred from direct assay	28035674	GOA
involved in cardiolipin biosynthetic process	IMP IMP: Inferred from mutant phenotype	19523918	GOA
involved in export across plasma membrane	IDA IDA: Inferred from direct assay	28035674	GOA
involved in export across plasma membrane	IMP IMP: Inferred from mutant phenotype	31091338	GOA
involved in lipid transport across blood-brain barrier	IMP IMP: Inferred from mutant phenotype	21395585	GOA
involved in long-chain fatty acid import across plasma membrane	IDA IDA: Inferred from direct assay	28035674	GOA
involved in long-chain fatty acid import across plasma membrane	IMP IMP: Inferred from mutant phenotype	28035674	GOA
involved in long-chain fatty acid import into cell	IMP IMP: Inferred from mutant phenotype	28178239	GOA
involved in long-chain fatty acid transport	IDA IDA: Inferred from direct assay	28035674	GOA
involved in long-chain fatty acid transport	IMP IMP: Inferred from mutant phenotype	21395585	GOA
involved in negative regulation of phospholipid biosynthetic process	IMP IMP: Inferred from mutant phenotype	19523918	GOA
involved in phosphatidic acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	19523918	GOA
involved in phosphatidylcholine biosynthetic process	IMP IMP: Inferred from mutant phenotype	19523918	GOA
involved in phosphatidylethanolamine biosynthetic process	IMP IMP: Inferred from mutant phenotype	19523918	GOA
involved in phosphatidylglycerol biosynthetic process	IMP IMP: Inferred from mutant phenotype	19523918	GOA
involved in phosphatidylinositol biosynthetic process	IMP IMP: Inferred from mutant phenotype	19523918	GOA
involved in phosphatidylserine biosynthetic process	IMP IMP: Inferred from mutant phenotype	19523918	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	28035674	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC27A1 Protein Structure

AMP-binding

AMP-binding_C

0
100
200
300
400
500
600
646 a.a.

Protein Preferred Names

Protein Names

long-chain fatty acid transport protein 1

arachidonate--CoA ligase

Related Diseases

Diseases

Alias

Ichthyosis Prematurity Syndrome

IPS	Ichthyosis Congenita Iv
Ichthyosis-Prematurity Syndrome	Congenital Ichthyosis Type 4

Lethal Restrictive Dermopathy

Hyperkeratosis-Contracture Syndrome	Tight Skin Contracture Syndrome
Tight Skin Contracture Syndrome, Lethal	Dermopathy, Restrictive, Lethal

Platelet Glycoprotein Iv Deficiency

Platelet-Type Bleeding Disorder 10	Bdplt10
Cd36 Deficiency	Bleeding Disorder, Platelet-Type, 10
PG4D	Bleeding Disorder Platelet-Type 10
Deficiency, Platelet Glycoprotein Iv

Melkersson-Rosenthal Syndrome

Melkersson Syndrome	Mros
Mrs	Cheilitis Granulomatosa Of Mescher-Melkersson-Rosenthal
Melkersson'S Syndrome	Cheilitis Granulomatosa
Granulomatous Cheilitis

Ichthyosis

Ichthyoses	Non-Syndromic Ichthyosis
Congenital Ichthyosis

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Persistent Fetal Circulation Syndrome

Persistent Fetal Circulation	Fetal Circulation
Persistent Pulmonary Hypertension Of The Newborn	Congenital Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Persistent Foetal Circulation	Persistent Foetal Circulation Syndrome
Pfc - [Persistent Fetal Circulation] Syndrome	Pphn - [Persistent Pulmonary Hypertension Of The Newborn]
Newborn Pulmonary Hypertension	Primary Pulmonary Hypertension Of Newborn

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16240	Slc27a1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13144	SLC27A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SLC27A1	VGNC	VGNC:77438
Mus musculus	SLC27A1	MGD	MGI:1347098
Felis catus	SLC27A1	VGNC	VGNC:65288
Canis familiaris	SLC27A1	VGNC	VGNC:46329
Bos taurus	SLC27A1	VGNC	VGNC:34785
Rattus norvegicus	SLC27A1	RGD	RGD:620927

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