KLRC2 - killer cell lectin like receptor C2 Gene

Homo sapiens

Also known as NKG2C; CD159c; NKG2-C

Gene ID: 3822 | Gene type: protein coding

About KLRC2

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,430,599-10,436,010 (from NCBI)

This gene has 5 transcripts (splice variants), 460 orthologues and 23 paralogues. Biased expression in brain (RPKM 6.7), spleen (RPKM 3.4) and 9 other tissues.

Summary

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

KLRC2 Products(1)

mRNA	Protein	Name
NM_002260.4	NP_002251.2	NKG2-C type II integral membrane protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables MHC class I protein complex binding	IPI IPI: Inferred from physical interaction	18448674	GOA
enables activating MHC class Ib receptor activity	IDA IDA: Inferred from direct assay	9754572	GOA
enables protein antigen binding	IDA IDA: Inferred from direct assay	18448674	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9655483	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in natural killer cell mediated immunity	IDA IDA: Inferred from direct assay	18448674	GOA
involved in positive regulation of natural killer cell degranulation	IDA IDA: Inferred from direct assay	21825173	GOA
involved in positive regulation of natural killer cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	9754572	GOA
involved in stimulatory C-type lectin receptor signaling pathway	IDA IDA: Inferred from direct assay	9655483	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	9655483	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	18448674	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLRC2 Protein Structure

Lectin_C

0
100
200
231 a.a.

Protein Preferred Names

Protein Names

NKG2-C type II integral membrane protein

CD159 antigen-like family member C

KLRC2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KLRC2	P26717	KLRD1	Homo sapiens	Q13241	BN-PAGE	32575403

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KLRC2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77807	NKG2C-CD94 Heterodimer Protein, Human (HEK293, His-Avi)	P26717 (E98-L231)&Q13241 (S34-I179)	≥95%
HY-P78006	NKG2C/CD159c Protein, Human (HEK293, His-Avi)	P26717 (E98-L231)	≥95%
HY-P700799	NKG2C/CD159c Protein, Human (Biotinylated, HEK293, His-Avi)	P26717 (E98-L231)	≥95%
HY-P700800	NKG2C/CD159c Protein, Human (HEK293, hFc)	P26717 (E98-L231)	≥95%

Related Diseases

Diseases

Alias

Human Cytomegalovirus Infection

Cytomegalovirus Infection

Cytomegalovirus Infections

Nk Cell Deficiency

Ceftazidime Allergy

Fortaz Allergy

Tazicef Allergy

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07392	KLRC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KLRC2	MGD	MGI:1336162
Rattus norvegicus	KLRC2	RGD	RGD:2977
Macaca fascicularis	KLRC2	NCBI

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