NPSR1 - neuropeptide S receptor 1 Gene

Homo sapiens

Also known as GPRA; NPSR; VRR1; ASRT2; PGR14; GPR154

Gene ID: 387129 | Gene type: protein coding

About NPSR1

Cytogenetic location: 7p14.3 Genomic coordinates (GRCh38): 7:34,658,218-34,878,332 (from NCBI)

This gene has 9 transcripts (splice variants), 382 orthologues and is associated with 1 phenotype. Low expression observed in reference dataset.

Summary

This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

NPSR1 Products(5)

mRNA	Protein	Name
NM_001300933.2	NP_001287862.1	neuropeptide S receptor isoform B short
NM_001300934.2	NP_001287863.1	neuropeptide S receptor isoform F
NM_001300935.2	NP_001287864.1	neuropeptide S receptor isoform G
NM_207172.2	NP_997055.1	neuropeptide S receptor isoform A
NM_207173.2	NP_997056.1	neuropeptide S receptor isoform B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables neuropeptide receptor activity	IDA IDA: Inferred from direct assay	16790440	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in neuropeptide signaling pathway	IDA IDA: Inferred from direct assay	15947423	GOA
involved in positive regulation of release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	16790440	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15947423	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15947423	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NPSR1 Protein Structure

7tm_1

0
100
200
300
371 a.a.

Protein Preferred Names

Protein Names

neuropeptide S receptor

G-protein coupled receptor 154

Related Diseases

Diseases

Alias

Asthma-Related Traits 2

Asthma-Related Traits, Susceptibility To, 2	ASRT2
Asthma, Susceptibility To, 2	Asthma 2
Asthma-Related Traits, Susceptibility To, Type 2

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Agoraphobia

Fear Of Open Spaces

Phobia Of Going Out

Allergic Asthma

Atopic Asthma	Extrinsic Asthma
Extrinsic Asthma With Acute Exacerbation	Extrinsic Asthma With Status Asthmaticus
Asthma Allergic	Atopic Asthma, Susceptibility To
Ige-Mediated Allergic Asthma	Allergen-Induced Asthma
Allergic Asthma Without Stated Status Asthmaticus	Predominantly Allergic Asthma Without Stated Status Asthmaticus
Predominantly Allergic Asthma	Allergic Asthma Nos
Catarrh With Asthma	Allergic Bronchitis Nos
Extrinsic Allergic Asthma	Predominantly Allergic Asthma With Stated Status Asthmaticus

Dermatitis

Eczema	Skin Inflammation
Inflammatory Dermatosis

Panic Disorder

Panic Anxiety Syndrome	Panic
Panic Disorder 1	Episodic Paroxysmal Anxiety Disorder

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Childhood-Onset Asthma

Childhood Asthma

Asthma Childhood

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09503	NPSR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NPSR1	VGNC	VGNC:32216
Macaca mulatta	NPSR1	VGNC	VGNC:81730
Rattus norvegicus	NPSR1	RGD	RGD:1564154
Felis catus	NPSR1	VGNC	VGNC:63875
Mus musculus	NPSR1	MGD	MGI:2441738
Canis familiaris	NPSR1	VGNC	VGNC:54789

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