SHISA2 - shisa family member 2 Gene

Homo sapiens

Also known as TMEM46; hShisa; C13orf13; PRO28631; WGAR9166; bA398O19.2

Gene ID: 387914 | Gene type: protein coding

About SHISA2

Cytogenetic location: 13q12.13 Genomic coordinates (GRCh38): 13:26,044,597-26,052,016 (from NCBI)

This gene has 1 transcript (splice variant), 195 orthologues and 5 paralogues. Biased expression in thyroid (RPKM 17.4), lung (RPKM 4.1) and 3 other tissues.

Summary

Predicted to be involved in negative regulation of Wnt signaling pathway and negative regulation of Fibroblast Growth Factor receptor signaling pathway. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

SHISA2 Products(1)

mRNA	Protein	Name
NM_001007538.2	NP_001007539.1	protein shisa-2 homolog precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SHISA2 Protein Structure

Shisa

0
100
200
295 a.a.

Protein Preferred Names

Protein Names

protein shisa-2 homolog

shisa homolog 2

Related Diseases

Diseases

Alias

Breast Medullary Carcinoma

Medullary Breast Carcinoma	Medullary Breast Carcinoma With Lymphoid Stroma
Medullary Carcinoma Of Breast

Mirror Movements 1

Congenital Mirror Movement Disorder	Bimanual Synergia
Congenital Mirror Movements	Familial Congenital Controlateral Synkinesia
Familial Congenital Mirror Movements	Hereditary Congenital Controlateral Synkinesia
Hereditary Congenital Mirror Movements	Isolated Congenital Controlateral Synkinesia
Isolated Congenital Mirror Movements	Mirror Movements
MRMV1	Mirror Movements 1 And/Or Agenesis Of The Corpus Callosum
Mirror Movements, Congenital	Bimanual Synkinesis
Cmm	Mirror Movements, Type 1

Nephronophthisis 11

NPHP11

Nephronophthisis, Type 11

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12866	SHISA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SHISA2	MGD	MGI:2444716
Felis catus	SHISA2	VGNC	VGNC:102318
Rattus norvegicus	SHISA2	RGD	RGD:1561256
Macaca mulatta	SHISA2	VGNC	VGNC:106294
Bos taurus	SHISA2	VGNC	VGNC:34598

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