MAP3K15 - mitogen-activated protein kinase kinase kinase 15 Gene

Homo sapiens

Also known as ASK3; bA723P2.3

Gene ID: 389840 | Gene type: protein coding

About MAP3K15

Cytogenetic location: Xp22.12 Genomic coordinates (GRCh38): X:19,360,059-19,515,508 (from NCBI)

This gene has 4 transcripts (splice variants), 195 orthologues and 2 paralogues. Ubiquitous expression in adrenal (RPKM 7.5), heart (RPKM 3.2) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic cell death triggered by cellular stresses. [provided by RefSeq, Jul 2010]

MAP3K15 Products(1)

mRNA	Protein	Name
NM_001001671.4	NP_001001671.3	mitogen-activated protein kinase kinase kinase 15

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables MAP kinase kinase kinase activity	IDA IDA: Inferred from direct assay	26732173	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP3K15 Protein Structure

DUF4071

Pkinase

0
300
600
900
1200
1313 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase kinase kinase 15

MAPK/ERK kinase kinase 15

Related Diseases

Diseases

Alias

Neuropathy, Hereditary Sensory And Autonomic, Type Iia

Hereditary Sensory And Autonomic Neuropathy Type 2	Hsan2
HSAN2A	Morvan Disease
Hereditary Sensory And Autonomic Neuropathy Type Ii	Neurogenic Acroosteolysis
Hsan Iia	Hsn2a
Hsn Iia	Neuropathy, Progressive Sensory, Of Children
Neuropathy, Congenital Sensory	Neuropathy, Hereditary Sensory And Autonomic, Type Ii
Hereditary Sensory And Autonomic Neuropathy Type 2a	Hereditary Sensory And Autonomic Neuropathy Type Iia
Hsanii	Congenital Sensory Neuropathy
Hsan Type Ii	Morvan Syndrome
Neuropathy, Hereditary Sensory And Autonomic, Type 2a	Morvan'S Disease
Neuropathy, Hereditary Sensory, Type Iia	Acroosteolysis, Neurogenic
Acroosteolysis, Giaccai Type	Neuropathy, Hereditary Sensory Radicular, Autosomal Recessive
Hereditary Sensory Autonomic Neuropathy Type 2	Giaccai Type Acroosteolysis
Hereditary Sensory Neuropathy Type 2	Hereditary Sensory Radicular Neuropathy, Recessive Form
Hsan2b	Hsan2c
Hsan2d	Hsn Type Ii
Autosomal Recessive Sensory Radicular Neuropathy	Limbic Encephalitis-Neuromyotonia-Hyperhidrosis-Polyneuropathy Syndrome
Morvan Fibrillary Chorea	Neuropathy, Hereditary Sensory And Autonomic, 2a
Acroosteolysis Giaccai Type	Hereditary Sensory Neuropathy Type Iia
Hereditary Sensory Radicular Neuropathy Autosomal Recessive	Progressive Sensory Neuropathy Of Children
Neuropathy Congenital Sensory	Charcot-Marie-Tooth Disease
Neuropathy, Sensory And Autonomic, Hereditary, Type Iia	Hereditary Sensory Autonomic Neuropathy, Type 2
Hereditary Motor And Sensory-Neuropathy Type Ii	Sensory Neuropathy, Hereditary
Neuropathy, Hereditary Sensory And Autonomic, Type Iib

Martin-Probst Syndrome

Deafness-Intellectual Disability, Martin-Probst Type Syndrome	Martin-Probst Deafness-Mental Retardation Syndrome
Mental Retardation, X-Linked, Syndromic, Martin-Probst Type	MRXSMP
Deafness-Intellectual Disability Syndrome, Martin-Probst Type	Hearing Loss-Intellectual Disability Syndrome, Martin-Probst Type
X-Linked Deafness-Intellectual Disability Syndrome Syndrome	X-Linked Hearing Loss-Intellectual Disability Syndrome Syndrome

Large Congenital Melanocytic Nevus

Giant Pigmented Hairy Nevus	Giant Congenital Melanocytic Nevus
Gmn	Congenital Pigmented Nevus
Lcmn	Gphn
Giant Congenital Nevus	Bathing Trunk Nevus
Congenital Giant Pigmented Nevus	Congenital Hairy Nevus
Giant Hairy Nevus	Giant Pigmented Nevus
Congenital Giant Pigmented Nevus Of Skin	Congenital Melanocytic Nevus Syndrome
Giant Congenital Melanocytic Nevi	Giant Congenital Pigmented Nevus
Melanocytic Nevus Syndrome, Congenital

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08052	MAP3K15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MAP3K15	VGNC	VGNC:63377
Mus musculus	MAP3K15	MGD	MGI:2448588
Bos taurus	MAP3K15	VGNC	VGNC:31193
Canis familiaris	MAP3K15	VGNC	VGNC:42971
Rattus norvegicus	MAP3K15	RGD	RGD:1560603
Others	MAP3K15	NCBI

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