KDM4E - lysine demethylase 4E Gene

Homo sapiens

Also known as KDM5E; JMJD2E; KDM4DL

Gene ID: 390245 | Gene type: protein coding

About KDM4E

Cytogenetic location: 11q21 Genomic coordinates (GRCh38): 11:95,025,258-95,027,596 (from NCBI)

This gene has 1 transcript (splice variant), 97 orthologues and 10 paralogues.

Summary

The protein encoded by this intronless gene is a member of a large family of histone lysine demethylases, which use oxygen and 2-oxoglutarate to demethylate di- and trimethylated lys9 of histone H3. Derepression of genes by demethylases is sometimes involved in viral Infection or carcinogenesis, so inhibitors of these Enzymes are desired. [provided by RefSeq, Dec 2016]

KDM4E Products(1)

mRNA	Protein	Name
NM_001161630.1	NP_001155102.1	lysine-specific demethylase 4E

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone H3K9me2/H3K9me3 demethylase activity	IDA IDA: Inferred from direct assay	21914792	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	21914792	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KDM4E Protein Structure

JmjN

JmjC

0
100
200
300
400
506 a.a.

Protein Preferred Names

Protein Names

lysine-specific demethylase 4E

KDM4D-like protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12304	IOX1	Inhibitor	99.72%	Unkown
HY-RS07217	KDM4E Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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