1. Gene
  2. LGALS9 - galectin 9 Gene

LGALS9 - galectin 9 Gene

Homo sapiens

Also known as HUAT; LGALS9A

Gene ID: 3965 | Gene type: protein coding

About LGALS9

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:27,631,188-27,649,560 (from NCBI)

This gene has 16 transcripts (splice variants), 353 orthologues and 16 paralogues. Broad expression in spleen (RPKM 33.5), stomach (RPKM 28.4) and 23 other tissues.

Summary

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

LGALS9 Products(3)

mRNA Protein Name
NM_001330163.2 NP_001317092.1 galectin-9 isoform 3
NM_002308.4 NP_002299.2 galectin-9 isoform short
NM_009587.3 NP_033665.1 galectin-9 isoform long
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables carbohydrate binding IDA
IDA: Inferred from direct assay
18977853 GOA
enables disaccharide binding IMP
IMP: Inferred from mutant phenotype
16116184 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
21670307 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
16116184 GOA
involved in cellular response to type II interferon IDA
IDA: Inferred from direct assay
23817958 GOA
involved in cellular response to virus IMP
IMP: Inferred from mutant phenotype
25754930 GOA
involved in female pregnancy IDA
IDA: Inferred from direct assay
23242525 GOA
involved in inflammatory response IDA
IDA: Inferred from direct assay
23817958 GOA
involved in maternal process involved in female pregnancy IDA
IDA: Inferred from direct assay
25578313 GOA
NOT involved in mature conventional dendritic cell differentiation IMP
IMP: Inferred from mutant phenotype
25754930 GOA
involved in natural killer cell tolerance induction IMP
IMP: Inferred from mutant phenotype
25578313 GOA
involved in negative regulation of CD4-positive, alpha-beta T cell proliferation IDA
IDA: Inferred from direct assay
20209097 GOA
involved in negative regulation of activated T cell proliferation IMP
IMP: Inferred from mutant phenotype
23817958 GOA
involved in negative regulation of chemokine production IMP
IMP: Inferred from mutant phenotype
25754930 GOA
involved in negative regulation of gene expression IDA
IDA: Inferred from direct assay
23408620 GOA
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
25578313 GOA
involved in negative regulation of mast cell degranulation IMP
IMP: Inferred from mutant phenotype
24465902 GOA
involved in negative regulation of natural killer cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
23408620 GOA
involved in negative regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
25578313 GOA
involved in negative regulation of type II interferon production IDA
IDA: Inferred from direct assay
23408620 GOA
involved in p38MAPK cascade IDA
IDA: Inferred from direct assay
16116184 GOA
involved in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response IDA
IDA: Inferred from direct assay
20209097 GOA
involved in positive regulation of CD4-positive, alpha-beta T cell proliferation IDA
IDA: Inferred from direct assay
16116184 GOA
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
24465902 GOA
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
25754930 GOA
involved in positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IDA
IDA: Inferred from direct assay
16116184 GOA
involved in positive regulation of activated T cell autonomous cell death IDA
IDA: Inferred from direct assay
20209097 GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
24465902 GOA
involved in positive regulation of dendritic cell apoptotic process IDA
IDA: Inferred from direct assay
16116184 GOA
involved in positive regulation of dendritic cell chemotaxis IMP
IMP: Inferred from mutant phenotype
25754930 GOA
involved in positive regulation of dendritic cell differentiation IMP
IMP: Inferred from mutant phenotype
16116184 GOA
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
16116184 GOA
involved in positive regulation of interleukin-1 beta production IDA
IDA: Inferred from direct assay
20209097 GOA
involved in positive regulation of interleukin-10 production IDA
IDA: Inferred from direct assay
16116184 GOA
involved in positive regulation of interleukin-12 production IMP
IMP: Inferred from mutant phenotype
16116184 GOA
involved in positive regulation of interleukin-13 production IDA
IDA: Inferred from direct assay
20209097 GOA
involved in positive regulation of interleukin-4 production IDA
IDA: Inferred from direct assay
20209097 GOA
involved in positive regulation of interleukin-4 production IMP
IMP: Inferred from mutant phenotype
25578313 GOA
involved in positive regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
24465902 GOA
involved in positive regulation of interleukin-8 production IMP
IMP: Inferred from mutant phenotype
24465902 GOA
involved in positive regulation of monocyte chemotactic protein-1 production IMP
IMP: Inferred from mutant phenotype
24465902 GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
25754930 GOA
involved in positive regulation of transforming growth factor beta production IDA
IDA: Inferred from direct assay
20209097 GOA
involved in positive regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
20209097 GOA
involved in positive regulation of type II interferon production IDA
IDA: Inferred from direct assay
20209097 GOA
involved in positive regulation of viral entry into host cell IDA
IDA: Inferred from direct assay
21670307 GOA
NOT involved in regulation of interleukin-4 production IDA
IDA: Inferred from direct assay
16116184 GOA
NOT involved in regulation of interleukin-5 production IDA
IDA: Inferred from direct assay
16116184 GOA
NOT involved in regulation of p38MAPK cascade IMP
IMP: Inferred from mutant phenotype
24465902 GOA
involved in response to interleukin-1 IDA
IDA: Inferred from direct assay
23817958 GOA
involved in response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
25578313 GOA
NOT involved in toll-like receptor 2 signaling pathway IDA
IDA: Inferred from direct assay
16116184 GOA
NOT involved in toll-like receptor 4 signaling pathway IDA
IDA: Inferred from direct assay
16116184 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
23242525 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
20209097 GOA
located in nucleus IDA
IDA: Inferred from direct assay
23242525 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LGALS9 Protein Structure

Gal-bind_lectin

Gal-bind_lectin: Galactoside-binding lectin (16 - 146)

Gal-bind_lectin

Gal-bind_lectin: Galactoside-binding lectin (226 - 354)

  • 0
  • 100
  • 200
  • 300
  • 355 a.a.
Protein Preferred Names Protein Names

galectin-9

ecalectin

Recombinant LGALS9 Proteins

Cat. No. Product Name Accession Purity
HY-P70535 Galectin-9/LGALS9 Protein, Human (HEK293, His) O00182-2 (M1-T323) ≥95%
HY-P70696 Galectin-9/LGALS9 Protein, Human (GST) O00182-2 (M1-T323) ≥95%
HY-P75176 Galectin-9/LGALS9 Protein, Human (HEK293, hFc) O00182-2 (A2-T323) ≥95%
HY-P700082AF Animal-Free Galectin-9/LGALS9 Protein, Human (His) O00182-2 (A2-T323) ≥95%

LGALS9 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81382 Galectin 9 Antibody (YA1127) IHC-P Human

Related Diseases

Diseases Alias
Dengue Virus

Dengue Virus, Susceptibility To

Dengue Fever, Protection Against

Dengue Fever

Patulous Eustachian Tube

Pet

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LGALS9 RGD RGD:3005
Mus musculus LGALS9 MGD MGI:109496
Others LGALS9 NCBI