2. Gene
  3. MAN2A2 - mannosidase alpha class 2A member 2 Gene

MAN2A2 - mannosidase alpha class 2A member 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MANA2X

Gene ID: 4122 | Gene type: protein coding

About MAN2A2

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:90,902,382-90,922,585 (from NCBI)

This gene has 30 transcripts (splice variants), 213 orthologues and 4 paralogues. Ubiquitous expression in bone marrow (RPKM 28.4), brain (RPKM 21.1) and 25 other tissues.

Summary

Predicted to enable alpha-mannosidase activity. Predicted to be involved in N-glycan processing and protein deglycosylation. Predicted to be integral component of membrane. Predicted to be active in Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022]

MAN2A2 Products(2)

mRNA Protein Name
NM_001320977.2 NP_001307906.1 alpha-mannosidase 2x isoform 2
NM_006122.4 NP_006113.2 alpha-mannosidase 2x isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
33961781 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAN2A2 Protein Structure

Glyco_hydro_38

Glyco_hydro_38: Glycosyl hydrolases family 38 N-terminal domain (167 - 497)

Alpha-mann_mid

Alpha-mann_mid: Alpha mannosidase middle domain (502 - 588)

Glyco_hydro_38C

Glyco_hydro_38C: Glycosyl hydrolases family 38 C-terminal domain (650 - 1146)

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  • 1150 a.a.
Protein Preferred Names Protein Names

alpha-mannosidase 2x

MAN IIx

Related Diseases

Diseases Alias
Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2

Abdominal Obesity-Metabolic Syndrome

Abdominal Obesity Metabolic Syndrome

Metabolic Syndrome X

Aoms2

Aoms1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08009 MAN2A2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08011 MAN2B2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MAN2A2 RGD RGD:1310238
Canis familiaris MAN2A2 VGNC VGNC:42946
Mus musculus MAN2A2 MGD MGI:2150656
Felis catus MAN2A2 VGNC VGNC:80922
Macaca mulatta MAN2A2 VGNC VGNC:81450
Bos taurus MAN2A2 VGNC VGNC:31165