MC3R - melanocortin 3 receptor Gene

Homo sapiens

Also known as MC3; OB20; OQTL; BMIQ9; MC3-R

Gene ID: 4159 | Gene type: protein coding

About MC3R

Cytogenetic location: 20q13.2 Genomic coordinates (GRCh38): 20:56,248,732-56,249,815 (from NCBI)

This gene has 1 transcript (splice variant), 141 orthologues, 18 paralogues and is associated with 2 phenotypes.

Summary

This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues Other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. [provided by RefSeq, Jul 2008]

MC3R Products(1)

mRNA	Protein	Name
NM_019888.3	NP_063941.3	melanocortin receptor 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables melanocyte-stimulating hormone receptor activity	IPI IPI: Inferred from physical interaction	19743876	GOA
enables neuropeptide binding	IMP IMP: Inferred from mutant phenotype	15927146	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19329486	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	19329486	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MC3R Protein Structure

7tm_1

0
100
200
300
323 a.a.

Protein Preferred Names

Protein Names

melanocortin receptor 3

obesity quantitative trait locus

Related Diseases

Diseases

Alias

Bardet-Biedl Syndrome

Bbs	Biedl-Bardet Syndrome

Uterine Carcinosarcoma

Carcinosarcoma Of The Corpus Uteri	Mixed Mullerian Sarcoma Of Uterus
Malignant Mixed Müllerian Tumor Of The Corpus Uteri	Malignant Mixed Müllerian Tumor Of Corpus Uteri
Mixed Müllerian Cancer Of Corpus Uteri	Malignant Mixed Mullerian Tumor Of The Corpus Uteri
Mixed Mullerian Cancer Of Corpus Uteri	Uterine Corpus Carcinosarcoma

Tricuspid Valve Disease

Rheumatic Tricuspid Valve Disease	Disease Of Tricuspid Valve
Rh. Tricuspid Valve Disease	Rheumatic Disease Of Tricuspid Valve
Tricuspid Disease	Tricuspid Valve Disorder

Hyperinsulinism

Hyperinsulinemia

Tricuspid Valve Insufficiency

Tricuspid Regurgitation	Tricuspid Valve Regurgitation
Tricuspid Incompetence	Tr - [Tricuspid Regurgitation]
Tricuspid Valve Incompetency	Tricuspid Valve Annular Incompetency

Body Mass Index Quantitative Trait Locus 9

Obesity	BMIQ9
Obesity, Susceptibility To	Obesity, Severe, Susceptibility To, Bmiq9
Obesity, Severe Bmiq9

Familial Glucocorticoid Deficiency

Glucocorticoid Deficiency	Acth Resistance
Adrenal Unresponsiveness To Acth	Hereditary Unresponsiveness To Adrenocorticotropic Hormone
Isolated Glucocorticoid Deficiency	Glucocorticoid Deficiency, Familial
Glucocorticoid Deficiency 1

Anorexia Nervosa

Anorexia Nervosa, Susceptibility To	ANON
Anorexia Nervosa, Susceptibility To, 1	An
Anorexia Nervosa 1	An - [Anorexia Nervosa]

Uterine Body Mixed Cancer

Malignant Mixed Tumor Of Corpus Uteri

Malignant Mixed Tumor, Not Otherwise Specified

Diabetes Mellitus

Diabetes

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
BMIQ11	Obesity Bmiq11
Obesity, Early-Onset	Obesity , Susceptibility To
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Diabetes Mellitus, Non-Insulin-Dependent	Type 2 Diabetes
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Leptin Deficiency Or Dysfunction

Morbid Obesity	Obesity Due To Congenital Leptin Deficiency
LEPD	Congenital Leptin Deficiency
Obesity, Morbid	Obesity, Morbid, Due To Leptin Deficiency
Severe Obesity	Obesity, Morbid, Nonsyndromic 1
Leptin Deficiency	Obesity, Severe, Due To Leptin Deficiency
Morbid Obesity Due To Leptin Deficiency	Obesity Morbid
Leptin Dysfunction	Leptin

Combat Disorder

Combat Disorders

Combat Neurosis

Hypoactive Sexual Desire Disorder

Lack Or Loss Of Sexual Desire

Sexual Dysfunctions, Psychological

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18678A	Bremelanotide Acetate	Agonist	99.98%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-147301	Resomelagon	Agonist	99.63%	Phase 2

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0227	SHU 9119		99.95%	Unkown
HY-P0097A	Nonapeptide-1 acetate salt	Antagonist	98.70%	Unkown
HY-P1214	γ1-MSH	Agonist	99.71%	Unkown
HY-P1217	[D-Trp8]-γ-MSH	Agonist	99.57%	Unkown
HY-P1531	γ-1-Melanocyte Stimulating Hormone (MSH), amide	Agonist	99.32%	Unkown
HY-P1209A	PG106 TFA	Antagonist	99.61%	Unkown
HY-P0097	Nonapeptide-1	Antagonist	99.04%	Unkown
HY-P1217A	[D-Trp8]-γ-MSH TFA	Agonist	/	Unkown
HY-P1214A	γ1-MSH TFA	Agonist	/	Unkown
HY-P0252B	α-MSH free acid	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MC3R	MGD	MGI:96929
Bos taurus	MC3R	VGNC	VGNC:31294
Canis familiaris	MC3R	VGNC	VGNC:110518
Felis catus	MC3R	VGNC	VGNC:68204
Rattus norvegicus	MC3R	RGD	RGD:3056
Macaca mulatta	MC3R	VGNC	VGNC:107799

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