MELTF - melanotransferrin Gene

Homo sapiens

Also known as MTf; MFI2; MTF1; CD228; MAP97

Gene ID: 4241 | Gene type: protein coding

About MELTF

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:197,001,740-197,029,817 (from NCBI)

This gene has 9 transcripts (splice variants), 199 orthologues and 3 paralogues. Broad expression in salivary gland (RPKM 9.5), kidney (RPKM 5.4) and 16 other tissues.

Summary

The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq, Jul 2008]

MELTF Products(2)

mRNA	Protein	Name
NM_005929.6	NP_005920.2	melanotransferrin isoform 1 preproprotein
NM_033316.4	NP_201573.1	melanotransferrin isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables iron ion binding	IMP IMP: Inferred from mutant phenotype	7556058	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19815549	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in iron ion transport	IMP IMP: Inferred from mutant phenotype	7556058	GOA
involved in negative regulation of substrate adhesion-dependent cell spreading	IDA IDA: Inferred from direct assay	16713448	GOA
involved in positive regulation of extracellular matrix disassembly	IDA IDA: Inferred from direct assay	16713448	GOA
involved in positive regulation of plasminogen activation	IDA IDA: Inferred from direct assay	16713448	GOA
NOT involved in regulation of cell growth	IMP IMP: Inferred from mutant phenotype	7556058	GOA
NOT involved in regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	7556058	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	7556058	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	7556058	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MELTF Protein Structure

Transferrin

0
200
400
600
738 a.a.

Protein Preferred Names

Protein Names

melanotransferrin

antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5

Recombinant MELTF Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700671	Melanotransferrin/CD228 Protein, Human (HEK293, His)	P08582-1 (G20-C709)	≥95%

Related Diseases

Diseases

Alias

Osteogenic Sarcoma

Osteosarcoma	OSRC
Osteosarcoma, Somatic	Neoplasms, Bone Tissue
Bone Tissue Neoplasm	Osteoid Sarcoma
Skeletal Sarcoma	Osteosarcoma Of Bone
Bone Sarcoma

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Melanotic Neuroectodermal Tumor

Melanotic Neuroectodermal Tumor Of Infancy	Neuroectodermal Tumor, Melanotic
Infantile Melanotic Neuroectodermal Neoplasm	Melanotic Neuroectodermal Tumour
Melanotic Neuroectodermal Tumour Of Infancy	Pigmented Neuroectodermal Tumour Of Infancy

Hemochromatosis, Type 1

Hemochromatosis	Hemochromatosis Type 1
Hereditary Hemochromatosis	Hh
HFE1	Hfe Hemochromatosis, Modifier Of
Symptomatic Form Of Classic Hemochromatosis	Symptomatic Form Of Hemochromatosis Type 1
Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis	Haemochromatosis
Iron Storage Disorder	Bronze Diabetes
Hereditary Haemochromatosis	Hlah
Hfe	Hemochromatosis, Hereditary
Diabetes Bronze	Classic Hemochromatosis
Hfe-Associated Hereditary Hemochromatosis	Hemochromatosis Classic
Bronzed Cirrhosis	Familial Hemochromatosis
Genetic Hemochromatosis	Hc
Pigmentary Cirrhosis	Primary Hemochromatosis
Troisier-Hanot-Chauffard Syndrome	Von Recklenhausen-Applebaum Disease
Hemochromatosis 1	Primary Hereditary Hemochromatosis
Bronze Cirrhosis

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08331	MELTF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MELTF	VGNC	VGNC:31383
Felis catus	MELTF	VGNC	VGNC:68243
Rattus norvegicus	MELTF	RGD	RGD:1308155
Mus musculus	MELTF	MGD	MGI:1353421
Canis familiaris	MELTF	VGNC	VGNC:43155
Macaca mulatta	MELTF	VGNC	VGNC:74711
Others	MELTF	NCBI

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