ASTN1 - astrotactin 1 Gene

Homo sapiens

Also known as ASTN

Gene ID: 460 | Gene type: protein coding

About ASTN1

Cytogenetic location: 1q25.2 Genomic coordinates (GRCh38): 1:176,857,321-177,164,712 (from NCBI)

This gene has 5 transcripts (splice variants), 215 orthologues and 1 paralogue. Biased expression in brain (RPKM 17.5), adrenal (RPKM 5.3) and 1 other tissue.

Summary

Astrotactin is a neuronal adhesion molecule required for glial-guided migration of young postmitotic neuroblasts in cortical regions of developing brain, including cerebrum, hippocampus, cerebellum, and olfactory bulb (Fink et al., 1995).[supplied by OMIM, Jun 2009]

ASTN1 Products(4)

mRNA	Protein	Name
NM_001286164.2	NP_001273093.1	astrotactin-1 isoform 3 precursor
NM_001364856.2	NP_001351785.1	astrotactin-1 isoform 4 precursor
NM_004319.3	NP_004310.1	astrotactin-1 isoform 1 precursor
NM_207108.3	NP_996991.1	astrotactin-1 isoform 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	31169361	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASTN1 Protein Structure

FXa_inhibition

0
200
400
600
800
1000
1200
1294 a.a.

Protein Preferred Names

Protein Names

astrotactin-1

Related Diseases

Diseases

Alias

Ritscher-Schinzel Syndrome 1

3c Syndrome	Craniocerebellocardiac Dysplasia
RTSC1	Dandy-Walker-Like Malformation With Atrioventricular Septal Defect
Dandy-Walker Like Malformation With Atrioventricular Septal Defect	Cranio-Cerebello-Cardiac Dysplasia
Dandy-Walker-Like Malformation With Asd	Ritscher Schinzel Syndrome
Ritscher-Schinzel Cranio-Cerebello-Cardiac Syndrome	Ritscher-Schinzel Syndrome
3c

Migraine, Familial Hemiplegic, 1

FHM1	Mhp1
Fhm	Familial Hemiplegic Migraine 1
Migraine, Familial Hemiplegic, 1, With Progressive Cerebellar Ataxia	Familial Hemiplegic Migraine1 With Progressive Cerebellar Ataxia
Migraine Familial Hemiplegic With Progressive Cerebellar Ataxia	Migraine, Hemiplegic, Familial, Type 1
Hemiplegic Migraine, Familial Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01112	ASTN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ASTN1	VGNC	VGNC:70167
Felis catus	ASTN1	VGNC	VGNC:68452
Canis familiaris	ASTN1	VGNC	VGNC:38194
Bos taurus	ASTN1	VGNC	VGNC:26227
Rattus norvegicus	ASTN1	RGD	RGD:727799
Mus musculus	ASTN1	MGD	MGI:1098567

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