NPAT - nuclear protein, coactivator of histone transcription Gene

Homo sapiens

Also known as E14; p220; E14/NPAT

Gene ID: 4863 | Gene type: protein coding

About NPAT

Cytogenetic location: 11q22.3 Genomic coordinates (GRCh38): 11:108,157,215-108,222,638 (from NCBI)

This gene has 6 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in lymph node (RPKM 6.0), spleen (RPKM 3.9) and 25 other tissues.

Summary

Enables protein C-terminus binding activity; transcription coactivator activity; and transcription corepressor activity. Involved in positive regulation of transcription by RNA polymerase II and regulation of transcription involved in G1/S transition of mitotic cell cycle. Located in Cajal body; Gemini of coiled bodies; and cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NPAT Products(2)

mRNA	Protein	Name
NM_001321307.1	NP_001308236.1	protein NPAT isoform 1
NM_002519.3	NP_002510.2	protein NPAT isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15988025	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	14585971	GOA
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	15988025	GOA
enables transcription corepressor activity	IMP IMP: Inferred from mutant phenotype	17163457	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell cycle G1/S phase transition	IMP IMP: Inferred from mutant phenotype	15988025	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18850719	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18850719	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15988025	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Cajal body	IDA IDA: Inferred from direct assay	15988025	GOA
located in Gemini of coiled bodies	IDA IDA: Inferred from direct assay	17068332	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17068332	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	17068332	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15988025	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein NPAT

nuclear protein of the ATM locus

Related Diseases

Diseases

Alias

Ataxia-Telangiectasia

Ataxia Telangiectasia	Louis-Bar Syndrome
AT	At1
Ataxia-Telangiectasia Syndrome	Ataxia - Telangiectasia Variant
Boder-Sedgwick Syndrome	Louis Bar Syndrome
Cerebello-Oculocutaneous Telangiectasia	Immunodeficiency With Ataxia Telangiectasia
A-T	Ataxia Telangiectasia Syndrome
Atm	Telangiectasia, Cerebello-Oculocutaneous
Ataxia-Telangiectasia Variant

Nasal Cavity Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Nasal Cavity

Squamous Cell Carcinoma Of The Nasal Cavity

Alpha Thalassemia-Intellectual Disability Syndrome Type 1

Alpha Thalassemia-Intellectual Disability Syndrome, Deletion Type	Alpha-Thalassemia-Intellectual Disability Syndrome Linked To Chromosome 16
Atr Syndrome Linked To Chromosome 16	Atr Syndrome, Deletion Type
Atr-16 Syndrome	Alpha Thalassemia-Retardation Syndrome
Alpha-Thalassemia/Mental Retardation Syndrome, Deletion-Type	Alpha-Thalassemia/Mental Retardation Syndrome, Type 1
Alpha-Thalassemia Mental Retardation Syndrome, Deletion-Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09472	NPAT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NPAT	VGNC	VGNC:50638
Mus musculus	NPAT	MGD	MGI:107605
Felis catus	NPAT	VGNC	VGNC:68527
Bos taurus	NPAT	VGNC	VGNC:50617
Rattus norvegicus	NPAT	RGD	RGD:1311947
Macaca mulatta	NPAT	VGNC	VGNC:75379

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