2. Gene
  3. OPCML - opioid binding protein/cell adhesion molecule like Gene

OPCML - opioid binding protein/cell adhesion molecule like Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as OPCM; OBCAM; IGLON1

Gene ID: 4978 | Gene type: protein coding

About OPCML

Cytogenetic location: 11q25 Genomic coordinates (GRCh38): 11:132,414,981-133,532,501 (from NCBI)

This gene has 8 transcripts (splice variants), 234 orthologues, 5 paralogues and is associated with 1 phenotype. Biased expression in brain (RPKM 9.6) and kidney (RPKM 0.2).

Summary

This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in Opioid Receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid Alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

OPCML Products(6)

mRNA Protein Name
NM_001012393.5 NP_001012393.1 opioid-binding protein/cell adhesion molecule isoform b precursor
NM_001319103.2 NP_001306032.1 opioid-binding protein/cell adhesion molecule isoform c precursor
NM_001319104.4 NP_001306033.1 opioid-binding protein/cell adhesion molecule isoform d
NM_001319105.2 NP_001306034.1 opioid-binding protein/cell adhesion molecule isoform e
NM_001319106.2 NP_001306035.1 opioid-binding protein/cell adhesion molecule isoform f precursor
NM_002545.5 NP_002536.1 opioid-binding protein/cell adhesion molecule isoform a preproprotein
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OPCML Protein Structure

I-set

I-set: Immunoglobulin I-set domain (38 - 132)

I-set

I-set: Immunoglobulin I-set domain (136 - 210)

I-set

I-set: Immunoglobulin I-set domain (227 - 311)

  • 0
  • 100
  • 200
  • 300
  • 345 a.a.
Protein Preferred Names Protein Names

opioid-binding protein/cell adhesion molecule

IgLON family member 1

OPCML Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
OPCML Q14982 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
OPCML Q14982 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
OPCML Q14982 NUP93 Homo sapiens Q8N1F7
Y2H Prey Pooling
32296183
Intra
OPCML Q14982 NUP93 Homo sapiens Q8N1F7
Validated Y2H
32296183
Intra
OPCML Q14982 NUP93 Homo sapiens Q8N1F7
Y2H Array
32296183
Intra
OPCML Q14982 KRTAP5-2 Homo sapiens Q701N4
Y2H Prey Pooling
32296183
Intra
OPCML Q14982 KRTAP5-2 Homo sapiens Q701N4
Validated Y2H
32296183
Intra
OPCML Q14982 KRTAP5-2 Homo sapiens Q701N4
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant OPCML Proteins

Cat. No. Product Name Accession Purity
HY-P76528 OBCAM/OPCML Protein, Human (HEK293, His) Q14982-1/NP_002536.1 (G28-N322) ≥95%

Related Diseases

Diseases Alias
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Hypogonadotropic Hypogonadism 14 With Or Without Anosmia

HH14

Hypogonadism, Hypogonadotropic, Type 14 With/Without Anosmia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09792 OPCML Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus OPCML RGD RGD:620635
Macaca mulatta OPCML VGNC VGNC:101370
Canis familiaris OPCML VGNC VGNC:54338
Felis catus OPCML VGNC VGNC:81968
Mus musculus OPCML MGD MGI:97397
Bos taurus OPCML VGNC VGNC:32435
Others OPCML NCBI