P2RX3 - purinergic receptor P2X 3 Gene

Homo sapiens

Also known as P2X3

Gene ID: 5024 | Gene type: protein coding

About P2RX3

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:57,335,950-57,372,396 (from NCBI)

This gene has 3 transcripts (splice variants), 275 orthologues and 6 paralogues. Biased expression in testis (RPKM 1.0), heart (RPKM 0.8) and 6 other tissues.

Summary

This gene encodes a member of the P2X purinergic receptor (purinoceptor) gene family which includes seven members (P2RX1 - P2RX7). P2X purinoceptors are a family of cation-permeable, ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). The encoded protein is a subunit of the trimeric P2X3 Receptor ion channel which is expressed by sensory or autonomic neurons. A deficiency of the orthologous protein in mice is associated with reduced pain-related behavior and urinary bladder hyporeflexia. [provided by RefSeq, Aug 2017]

P2RX3 Products(7)

mRNA	Protein	Name
XR_949950.3
XM_011545069.3	XP_011543371.1	P2X purinoceptor 3 isoform X1
XM_011545073.2	XP_011543375.1	P2X purinoceptor 3 isoform X4
XM_011545071.3	XP_011543373.1	P2X purinoceptor 3 isoform X2
XM_011545072.3	XP_011543374.1	P2X purinoceptor 3 isoform X3
XM_011545070.3	XP_011543372.1	P2X purinoceptor 3 isoform X1
NM_002559.5	NP_002550.2	P2X purinoceptor 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	27626375	GOA
enables extracellularly ATP-gated monoatomic cation channel activity	IDA IDA: Inferred from direct assay	27626375	GOA
enables purinergic nucleotide receptor activity	IDA IDA: Inferred from direct assay	27626375	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to ATP	IDA IDA: Inferred from direct assay	27626375	GOA
involved in inorganic cation transmembrane transport	IDA IDA: Inferred from direct assay	27626375	GOA
involved in protein homotrimerization	IDA IDA: Inferred from direct assay	27626375	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	27626375	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2RX3 Protein Structure

P2X_receptor

0
100
200
300
397 a.a.

Protein Preferred Names

Protein Names

P2X purinoceptor 3

ATP receptor	P2X receptor, subunit 3
purinergic receptor P2X, ligand gated ion channel, 3	purinergic receptor P2X3
purinoceptor P2X3

Related Diseases

Diseases

Alias

Chronic Interstitial Cystitis

Migraine, Familial Hemiplegic, 1

FHM1	Mhp1
Fhm	Familial Hemiplegic Migraine 1
Migraine, Familial Hemiplegic, 1, With Progressive Cerebellar Ataxia	Familial Hemiplegic Migraine1 With Progressive Cerebellar Ataxia
Migraine Familial Hemiplegic With Progressive Cerebellar Ataxia	Migraine, Hemiplegic, Familial, Type 1
Hemiplegic Migraine, Familial Type 1

Migraine With Aura

Classic Migraine	Migraine With Typical Aura
Migraine Accompagnée	Complicated Migraine
Classical Migraine	Acute Migraine With Aura

Peripheral Nervous System Disease

Peripheral Neuropathy	Peripheral Nerve Disease
Peripheral Nerve Disorders	Neuropathy, Peripheral
Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Paine Syndrome

Pain Disorder	Pain
Microcephaly With Spastic Diplegia	Pain Syndrome

Deafness, Autosomal Dominant 41

DFNA41	Autosomal Dominant Nonsyndromic Deafness 41
Autosomal Dominant Deafness 41	Deafness, Autosomal Dominant, 41
Deafness, Autosomal Dominant, Type 41

Reflex Sympathetic Dystrophy

Algodystrophy	Complex Regional Pain Syndrome Type 1
Reflex Sympathetic Dystrophy Syndrome	Complex Regional Pain Syndromes
Algodystrophic Syndrome

Trigeminal Neuralgia

Tic Douloureux	Trifacial Neuralgia
Trifocal Neuralgia	Neuralgia Of The Fifth Cranial Nerve
Neuralgia Of 5th Cranial Nerve	Infraorbital Neuralgia

Complex Regional Pain Syndrome

Complex Regional Pain Syndromes	Reflex Sympathetic Dystrophy
Crps

Chronic Pain

Urethral Syndrome

Urethral Disease	Urethral Diseases
Urethra Disease	Abnormality Of The Urethra
Urethral Disorders

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Erythromelalgia

Primary Erythromelalgia	Erythermalgia
Primary Erythermalgia	Mitchell Disease
Familial Erythromelalgia

Alcoholic Neuropathy

Alcoholic Polyneuropathy	Alcohol-Related Polyneuropathy
Alcohol-Induced Polyneuropathy	Alcoholic Peripheral Neuropathy

Agnosia

Dyspraxia	Primary Visual Agnosia
Dyspraxia Syndrome	Monomodal Visual Amnesia
Visual Amnesia	Agnosia, Primary Visual
Apraxias	Alexia

Femoral Cancer

Femoral Neoplasms	Cancer Of The Femur
Femoral Neoplasm	Neoplasm Of Femur

Fibromyalgia

Diffuse Myofascial Pain Syndrome	Fibromyalgia Syndrome
Fibromyalgia-Fibromyositis Syndrome	Fibromyositis
Fibrositis	Fms
Myofascial Pain Syndrome	Myofascial Pain Syndromes

Glossopharyngeal Neuralgia

Glossopharyngeal Nerve Diseases

Ischemic Neuropathy

Ischemic Peripheral Neuropathy

Familial Hemiplegic Migraine

Hemiplegic Migraine, Familial	Hemiplegic-Ophthalmoplegic Migraine
Fhm	Hemiplegic Migraine Familial

Burning Mouth Syndrome

Orodynia	Stomatodynia
Stomatopyrosis	Bms
Burning Mouth Disorder	Oral Dysesthesia
Sore Mouth Syndrome	Bms - [Burning Mouth Syndrome]

Cystitis

Infective Cystitis	Urocystitis
Pyocystitis

Trigeminal Nerve Disease

Trigeminal Nerve Diseases	Disorders Of 5th Cranial Nerve
Disorders Of The Fifth Cranial Nerve

Chronic Cystitis

Cough Variant Asthma

Somatoform Disorder

Physiological Malfunction Arising From Mental Factor	Psychosomatic Disorder
Psychophysiologic Disorders

Neurogenic Bladder

Neurogenic Dysfunction Of The Urinary Bladder	Neurogenic Urinary Bladder Disorder
Neuropathic Bladder	Bladder Neurogenic
Urinary Bladder, Neurogenic	Neurogenic Urinary Bladder

Low Compliance Bladder

Overactive Bladder	Hyperactivity Of Bladder
Hypertonic Bladder	Hypertonicity Of Bladder
Low Bladder Compliance	Oab - [Overactive Bladder]

Pain Agnosia

Analgesia

Detrusor Sphincter Dyssynergia

Detrusor And Sphincter Dyssynergia

Interstitial Cystitis

Bladder Pain Syndrome	Painful Bladder Syndrome
Ulcerative Cystitis	Ic/Bps
Ic/Pbs	Interstitial Cystitis/Bladder Pain Syndrome
Interstitial Cystitis/Painful Bladder Syndrome	Cystitis, Interstitial
Chronic Interstitial Cystitis	Pelvic Congestion Syndrome
Trigonitis

Myofascial Pain Syndrome

Myofascial Pain Syndromes	Myofascial Pain Dysfunction Syndrome
Fibromyalgia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09903	P2RX3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09904	P2rx3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09905	P2rx3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	P2RX3	RGD	RGD:620253
Felis catus	P2RX3	VGNC	VGNC:68670
Bos taurus	P2RX3	VGNC	VGNC:32519
Canis familiaris	P2RX3	VGNC	VGNC:44209
Mus musculus	P2RX3	MGD	MGI:1097160
Macaca mulatta	P2RX3	VGNC	VGNC:75733
Others	P2RX3	NCBI