IL21R - interleukin 21 receptor Gene

Homo sapiens

Also known as NILR; CD360; IMD56

Gene ID: 50615 | Gene type: protein coding

About IL21R

Cytogenetic location: 16p12.1 Genomic coordinates (GRCh38): 16:27,402,174-27,452,042 (from NCBI)

This gene has 6 transcripts (splice variants), 131 orthologues, 7 paralogues and is associated with 70 phenotypes. Biased expression in lymph node (RPKM 10.1), appendix (RPKM 5.4) and 7 other tissues.

Summary

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I Cytokine Receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]

IL21R Products(3)

mRNA	Protein	Name
NM_021798.4	NP_068570.1	interleukin-21 receptor isoform 1 precursor
NM_181078.3	NP_851564.1	interleukin-21 receptor isoform 1 precursor
NM_181079.5	NP_851565.4	interleukin-21 receptor isoform 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytokine receptor activity	IDA IDA: Inferred from direct assay	11016959	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables transmembrane signaling receptor activity	IDA IDA: Inferred from direct assay	11016959	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

interleukin-21 receptor

IL-21 receptor

Recombinant IL21R Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72559	IL-21R Protein, Human (HEK293, His)	Q9HBE5 (C20-P236)	≥95%
HY-P77714	IL-21R Protein, Human (HEK293, Fc)	Q9HBE5 (C20-P236)	≥95%

Related Diseases

Diseases

Alias

Immunodeficiency 56

Il21r Immunodeficiency	IMD56
Combined Immunodeficiency Due To Il21r Deficiency	Autosomal Recessive Primary Immunodeficiency Il21r-Related

Ige Responsiveness, Atopic

ATOPY	Atopy, Susceptibility To
Ige, Elevated Level Of	IGER
Immunoglobulin E, Basic Level Of, In Serum	Ige, Level Of
Igel	Ige Response Underlying Allergic Asthma And Rhinitis
Atopic Hypersensitivity	Immediate Hypersensitivity

Immunodeficiency 31c

IMD31C	Candidiasis, Familial, 7
Candf7	Candidiasis, Familial Chronic Mucocutaneous, Autosomal Dominant
Autoimmune Enteropathy And Endocrinopathy-Susceptibility To Chronic Infections Syndrome	Autoimmune Enteropathy And Endocrinopathy - Susceptibility To Chronic Infections Syndrome
Immunodeficiency 31c, Chronic Mucocutaneous Candidiasis, Autosomal Dominant	Autosomal Dominant Chronic Mucocutaneous Familial Candidiasis
Autosomal Dominant Immunodeficiency 31c	Familial Candidiasis 7
Chronic Mucocutaneous Candidiasis 7	Immunodeficiency 31c, Autosomal Dominant
Immunodeficiency, Type 31c, Autosomal Dominant

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Common Variable Immunodeficiency

Cvid	Common Variable Agammaglobulinemia
Common Variable Immune Deficiency	Acquired Hypogammaglobulinemia
Hypogamma-Globulinemia, Acquired	Idiopathic Immunoglobulin Deficiency
Primary Antibody Deficiency	Primary Hypogammaglobulinemia
Acquired Agammaglobulinemia	Sporadic Hypogammaglobulinemia
Common Variable Hypogamma-Globulinemia	Immunoglobulin Deficiency, Late-Onset
Common Variable Hypogammaglobulinemia	Immunodeficiency, Common Variable

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06735	IL21R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	IL21R	VGNC	VGNC:73727
Mus musculus	IL21R	MGD	MGI:1890475
Rattus norvegicus	IL21R	RGD	RGD:1304950
Felis catus	IL21R	VGNC	VGNC:67775
Canis familiaris	IL21R	VGNC	VGNC:41968
Bos taurus	IL21R	VGNC	VGNC:30142
Macaca fascicularis	IL21R	NCBI	NCBI:102135042
Others	IL21R	NCBI

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