2. Gene
  3. Chek2 - checkpoint kinase 2 Gene

Chek2 - checkpoint kinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CHK2; Cds1; Rad53; HUCDS1

Gene ID: 50883 | Gene type: protein coding

About Chek2

Chromosome 5: 110,987,845-111,022,011 forward strand.GRCm39:CM000998.3

This gene has 6 transcripts (splice variants), 206 orthologues and is associated with 8 phenotypes. Broad expression in liver E14 (RPKM 9.9), liver E14.5 (RPKM 8.7) and 23 other tissues.

Summary

Enables protein kinase activity. Acts upstream of or within cellular response to gamma radiation; peptidyl-serine phosphorylation; and signal transduction by p53 class mediator. Predicted to be located in Golgi apparatus and PML body. Predicted to be active in cytoplasm and nucleus. Predicted to colocalize with chromosome, telomeric region. Is expressed in several structures, including central nervous system; genitourinary system; and liver. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome 2; breast Cancer (multiple); colorectal cancer; osteosarcoma; and prostate Cancer. Orthologous to human CHEK2 (checkpoint kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Chek2 Products(2)

mRNA Protein Name
NM_001363308.1 NP_001350237.1 serine/threonine-protein kinase Chk2 isoform 2
NM_016681.4 NP_057890.1 serine/threonine-protein kinase Chk2 isoform 1

Chek2 Protein Structure

FHA_CHK2

FHA_CHK2: cd22666 (96 - 207)

STKc_Chk2

STKc_Chk2: cd14084 (216 - 489)

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  • 546 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase Chk2

CHK2 checkpoint homolog

Cds1 homolog

Rad53 homolog

Recombinant Chek2 Proteins

Cat. No. Product Name Accession Purity
HY-P75348 CHEK2 Protein, Mouse (sf9, His-GST) Q9Z265 (M1-L546) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02619 CHEK2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS02620 Chek2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS02621 Chek2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chek2 NCBI NCBI:11200