CPA4 - carboxypeptidase A4 Gene

Homo sapiens

Also known as CPA3

Gene ID: 51200 | Gene type: protein coding

About CPA4

Cytogenetic location: 7q32.2 Genomic coordinates (GRCh38): 7:130,293,161-130,324,180 (from NCBI)

This gene has 11 transcripts (splice variants), 126 orthologues and 8 paralogues. Biased expression in skin (RPKM 24.3) and esophagus (RPKM 4.3).

Summary

This gene is a member of the Carboxypeptidase A/B subfamily, and it is located in a cluster with three Other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal Amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate Cancer aggressiveness. [provided by RefSeq, Jul 2008]

CPA4 Products(2)

mRNA	Protein	Name
NM_001163446.2	NP_001156918.1	carboxypeptidase A4 isoform 2 precursor
NM_016352.4	NP_057436.2	carboxypeptidase A4 isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables metallocarboxypeptidase activity	IDA IDA: Inferred from direct assay	20385563	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23746805	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in hormone catabolic process	IDA IDA: Inferred from direct assay	20385563	GOA
involved in peptide catabolic process	IDA IDA: Inferred from direct assay	20385563	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	20385563	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPA4 Protein Structure

Propep_M14

Peptidase_M14

0
100
200
300
421 a.a.

Protein Preferred Names

Protein Names

carboxypeptidase A4

carboxypeptidase A3

Related Diseases

Diseases

Alias

Thiopental Allergy

Penthiobarbital Allergy

Pentothiobarbital Allergy

Esophagitis, Eosinophilic, 1

Eosinophilic Esophagitis	EOE1
Esophagitis, Eosinophilic	Ee

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03083	CPA4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CPA4	VGNC	VGNC:61114
Bos taurus	CPA4	VGNC	VGNC:107220
Mus musculus	CPA4	MGD	MGI:1919041
Macaca mulatta	CPA4	VGNC	VGNC:71411
Canis familiaris	CPA4	VGNC	VGNC:39545
Rattus norvegicus	CPA4	RGD	RGD:1563619
Others	CPA4	NCBI

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