TRAPPC4 - trafficking protein particle complex subunit 4 Gene

Homo sapiens

Also known as SBDN; TRS23; PTD009; CGI-104; HSPC172; NEDESBA; SYNBINDIN

Gene ID: 51399 | Gene type: protein coding

About TRAPPC4

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:119,018,766-119,024,134 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 214 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 25.2), adrenal (RPKM 22.1) and 25 other tissues.

Summary

Involved in Autophagy and endoplasmic reticulum to Golgi vesicle-mediated transport. Part of TRAPP complex. [provided by Alliance of Genome Resources, Apr 2022]

TRAPPC4 Products(7)

mRNA	Protein	Name
NM_001318486.2	NP_001305415.1	trafficking protein particle complex subunit 4 isoform 2 precursor
NM_001318488.2	NP_001305417.1	trafficking protein particle complex subunit 4 isoform 3
NM_001318489.2	NP_001305418.1	trafficking protein particle complex subunit 4 isoform 4
NM_001318490.2	NP_001305419.1	trafficking protein particle complex subunit 4 isoform 5
NM_001318492.2	NP_001305421.1	trafficking protein particle complex subunit 4 isoform 6
NM_001318494.2	NP_001305423.1	trafficking protein particle complex subunit 4 isoform 7
NM_016146.6	NP_057230.1	trafficking protein particle complex subunit 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17110339	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in autophagy	IMP IMP: Inferred from mutant phenotype	31794024	GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	31794024	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of TRAPP complex	IDA IDA: Inferred from direct assay	21525244	GOA
part of TRAPP complex	IMP IMP: Inferred from mutant phenotype	31794024	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRAPPC4 Protein Structure

Sybindin

0
100
200
219 a.a.

Protein Preferred Names

Protein Names

trafficking protein particle complex subunit 4

TRS23 homolog

Related Diseases

Diseases

Alias

Neurodevelopmental Disorder With Epilepsy, Spasticity, And Brain Atrophy

NEDESBA

Neurodevelopmental Disorder With Progressive Microcephaly, Spasticity, And Brain Anomalies

NDMSBA	Plaa-Associated Neurodevelopmental Disorder
Plaand

Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder

Spondyloepiphyseal Dysplasia Tarda, X-Linked

Spondyloepiphyseal Dysplasia Tarda	X-Linked Spondyloepiphyseal Dysplasia Tarda
SEDT	Sed Tarda, X-Linked
Spondyloepiphyseal Dysplasia, Late	Spondyloepiphyseal Dysplasia Tarda X-Linked
Sed	X Linked Spondyloepiphyseal Dysplasia Tarda
X-Linked Spondyloepiphyseal Dysplasia	Late Onset Spondyloepiphyseal Dysplasia
Sed Tarda	X-Linked Sed
X-Linked Sedt	Dysplasia, Spondyloepiphyseal, Tarda
Spondyloepiphyseal Dysplasia

Neu-Laxova Syndrome 2

NLS2

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14991	TRAPPC4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TRAPPC4	MGD	MGI:1926211
Felis catus	TRAPPC4	VGNC	VGNC:66513
Bos taurus	TRAPPC4	VGNC	VGNC:36290
Rattus norvegicus	TRAPPC4	RGD	RGD:1302991
Canis familiaris	TRAPPC4	VGNC	VGNC:47783
Macaca mulatta	TRAPPC4	VGNC	VGNC:79211

Name
Email *

	Sorry, but the email address you supplied was invalid.