YTHDF2 - YTH N6-methyladenosine RNA binding protein 2 Gene

Homo sapiens

Also known as DF2; CAHL; HGRG8; NY-REN-2

Gene ID: 51441 | Gene type: protein coding

About YTHDF2

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:28,736,624-28,769,775 (from NCBI)

This gene has 9 transcripts (splice variants), 214 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 23.8), testis (RPKM 20.2) and 25 other tissues.

Summary

This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in Plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012]

YTHDF2 Products(3)

mRNA	Protein	Name
NM_001172828.2	NP_001166299.1	YTH domain-containing family protein 2 isoform 2
NM_001173128.2	NP_001166599.1	YTH domain-containing family protein 2 isoform 1
NM_016258.3	NP_057342.2	YTH domain-containing family protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables C5-methylcytidine-containing RNA reader activity	IDA IDA: Inferred from direct assay	31815440	GOA
enables N6-methyladenosine-containing RNA reader activity	IDA IDA: Inferred from direct assay	22575960	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24965446	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA catabolic process	IDA IDA: Inferred from direct assay	27558897	GOA
involved in mRNA destabilization	IDA IDA: Inferred from direct assay	27558897	GOA
involved in mRNA destabilization	IMP IMP: Inferred from mutant phenotype	28106072	GOA
involved in negative regulation of stem cell differentiation	IMP IMP: Inferred from mutant phenotype	32169943	GOA
involved in negative regulation of type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	30559377	GOA
involved in organelle assembly	IDA IDA: Inferred from direct assay	31292544	GOA
involved in positive regulation of cap-independent translational initiation	IDA IDA: Inferred from direct assay	26458103	GOA
NOT involved in positive regulation of translational initiation	IDA IDA: Inferred from direct assay	32492408	GOA
involved in regulation of mRNA stability	IDA IDA: Inferred from direct assay	32492408	GOA
involved in regulation of mRNA stability	IMP IMP: Inferred from mutant phenotype	24284625	GOA
involved in regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	32169943	GOA
involved in regulation of rRNA processing	IMP IMP: Inferred from mutant phenotype	31815440	GOA
involved in stress granule assembly	IDA IDA: Inferred from direct assay	32451507	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in P-body	IDA IDA: Inferred from direct assay	24284625	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	32492408	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	31292544	GOA
located in cytosol	IDA IDA: Inferred from direct assay	26458103	GOA
located in nucleus	IDA IDA: Inferred from direct assay	26458103	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YTHDF2 Protein Structure

YTH

0
100
200
300
400
500
579 a.a.

Protein Preferred Names

Protein Names

YTH domain-containing family protein 2

9430020E02Rik

Related Diseases

Diseases

Alias

Myeloid Leukemia

Myeloid Leukaemia	Leukaemia Myelogenous
Leukemia Myelogenous	Myeloid Granulocytic Leukaemia
Myeloid Granulocytic Leukemia	Non-Lymphocytic Leukemia
Leukemia, Myeloid	Granulocytic Leukaemia
Myelogenous Leukaemia	Myeloid Leukaemia, Unspecified, Without Mention Of Remission

Ocular Melanoma

Intraocular Melanoma	Uveal Melanoma
Eye Melanoma	Melanoma Of Eye
Melanoma Of The Uvea	Malignant Melanoma Of Eye

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-154919	DC-Y13-27	Inhibitor	99.52%	Unkown
HY-168610	YTH-IN-1	Inhibitor	/	Unkown
HY-173008	YTHDF2-IN-1	Inhibitor	/	Unkown
HY-RS15938	YTHDF2 Human Pre-designed siRNA Set A	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	YTHDF2	VGNC	VGNC:37042
Mus musculus	YTHDF2	MGD	MGI:2444233
Felis catus	YTHDF2	VGNC	VGNC:67152
Macaca mulatta	YTHDF2	VGNC	VGNC:79912
Rattus norvegicus	YTHDF2	RGD	RGD:1311321
Canis familiaris	YTHDF2	VGNC	VGNC:48506
Others	YTHDF2	NCBI

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