ASB4 - ankyrin repeat and SOCS box containing 4 Gene

Homo sapiens

Also known as ASB-4

Gene ID: 51666 | Gene type: protein coding

About ASB4

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:95,470,656-95,551,317 (from NCBI)

This gene has 3 transcripts (splice variants), 192 orthologues and 7 paralogues. Biased expression in adrenal (RPKM 15.4) and placenta (RPKM 0.7).

Summary

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known. [provided by RefSeq, Jul 2008]

ASB4 Products(2)

mRNA	Protein	Name
NM_016116.3	NP_057200.1	ankyrin repeat and SOCS box protein 4 isoform a
NM_145872.3	NP_665879.1	ankyrin repeat and SOCS box protein 4 isoform b

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cul2-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	17636018	GOA
part of Cul5-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	17636018	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASB4 Protein Structure

Ank_2

Ank_3

Ank_2

SOCS_box

0
100
200
300
400
426 a.a.

Protein Preferred Names

Protein Names

ankyrin repeat and SOCS box protein 4

Related Diseases

Diseases

Alias

Citrullinemia, Type Ii, Neonatal-Onset

NICCD	Citrin Deficiency
Neonatal Intrahepatic Cholestasis Due To Citrin Deficiency	Citrullinemia, Type Ii, Neonatal-Onset, With Or Without Failure To Thrive And Dyslipidemia
Cholestasis, Neonatal Intrahepatic, Caused By Citrin Deficiency	Neonatal-Onset Type Ii Citrullinemia
Neonatal Intrahepatic Cholestasis Caused By Citrin Deficiency	Neonatal-Onset Citrullinemia Type 2
Neonatal-Onset Citrullinemia Type Ii	Neonatal-Onset Type 2 Citrullinemia
Adult-Onset Citrullinemia Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01069	ASB4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ASB4	VGNC	VGNC:69353
Mus musculus	ASB4	MGD	MGI:1929751
Rattus norvegicus	ASB4	RGD	RGD:1563114
Macaca mulatta	ASB4	VGNC	VGNC:80796
Canis familiaris	ASB4	VGNC	VGNC:38164
Bos taurus	ASB4	VGNC	VGNC:26197

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