2. Gene
  3. PFKFB3 - 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Gene

PFKFB3 - 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PFK2; IPFK2; iPFK-2

Gene ID: 5209 | Gene type: protein coding

About PFKFB3

Cytogenetic location: 10p15.1 Genomic coordinates (GRCh38): 10:6,144,921-6,326,637 (from NCBI)

This gene has 19 transcripts (splice variants), 209 orthologues and 3 paralogues. Biased expression in fat (RPKM 188.2), bone marrow (RPKM 67.0) and 9 other tissues.

Summary

The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of Apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]

PFKFB3 Products(7)

mRNA Protein Name
NM_001145443.3 NP_001138915.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 2
NM_001282630.3 NP_001269559.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 3
NM_001314063.2 NP_001300992.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 4
NM_001323016.2 NP_001309945.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 5
NM_001323017.2 NP_001309946.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 6
NM_001363545.2 NP_001350474.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 7
NM_004566.4 NP_004557.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 1

PFKFB3 Protein Structure

6PF2K

6PF2K: 6-phosphofructo-2-kinase (26 - 246)

His_Phos_1

His_Phos_1: Histidine phosphatase superfamily (branch 1) (248 - 395)

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  • 520 a.a.
Protein Preferred Names Protein Names

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase

Recombinant PFKFB3 Proteins

Cat. No. Product Name Accession Purity
HY-P71199 PFKFB3 Protein, Human (His) Q16875 (M1-H520) ≥95%
HY-P74636 PFKFB3 Protein, Human (sf9, His-GST) Q16875-1 (M1-H520) ≥95%

Related Diseases

Diseases Alias
Colon Adenocarcinoma

Adenocarcinoma Of Colon

Adenocarcinoma Of The Colon

Colonic Adenocarcinoma
Glycogen Storage Disease

Glycogenosis

Glycogenoses

Gsd

Storage Disease, Glycogen

Gsd - [Glycogen Storage Disease]

Glycogen Thesaurismosis

Diffuse Glycogenosis

Generalised Glycogen Storage Disease

Generalised Glycogenosis

Generalised Glycogen Storage Disease Of Infants

Glycogen Synthase Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-12203 PFK-158 Inducer 98.88% Phase 1
Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-19824 3PO Inhibitor 99.56% Unkown
HY-12204 PFK-015 Inhibitor 99.80% Unkown
HY-123981 5MPN 99.72% Unkown
HY-101972 AZ-PFKFB3-67 Inhibitor 97.20% Unkown
HY-101971 AZ PFKFB3 26 Inhibitor 99.23% Unkown
HY-110156 YZ9 98.56% Unkown
HY-112808 KAN0438757 Inhibitor 99.41% Unkown
HY-153077 PFKFB3-IN-2 Inhibitor 99.53% Unkown
HY-101972A AZ-PFKFB3-67 quarterhydrate Inhibitor ≥99.0% Unkown
HY-RS10363 PFKFB3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PFKFB3 VGNC VGNC:32771
Macaca mulatta PFKFB3 VGNC VGNC:75959
Felis catus PFKFB3 VGNC VGNC:68805
Canis familiaris PFKFB3 VGNC VGNC:44444
Rattus norvegicus PFKFB3 RGD RGD:619776
Mus musculus PFKFB3 MGD MGI:2181202
Others PFKFB3 NCBI