PFKFB3 - 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Gene

Homo sapiens

Also known as PFK2; IPFK2; iPFK-2

Gene ID: 5209 | Gene type: protein coding

About PFKFB3

Cytogenetic location: 10p15.1 Genomic coordinates (GRCh38): 10:6,144,921-6,326,637 (from NCBI)

This gene has 19 transcripts (splice variants), 209 orthologues and 3 paralogues. Biased expression in fat (RPKM 188.2), bone marrow (RPKM 67.0) and 9 other tissues.

Summary

The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of Apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]

PFKFB3 Products(7)

mRNA	Protein	Name
NM_001145443.3	NP_001138915.1	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 2
NM_001282630.3	NP_001269559.1	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 3
NM_001314063.2	NP_001300992.1	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 4
NM_001323016.2	NP_001309945.1	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 5
NM_001323017.2	NP_001309946.1	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 6
NM_001363545.2	NP_001350474.1	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 7
NM_004566.4	NP_004557.1	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables 6-phosphofructo-2-kinase activity	IDA IDA: Inferred from direct assay	10077634	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PFKFB3 Protein Structure

6PF2K

His_Phos_1

0
100
200
300
400
520 a.a.

Protein Preferred Names

Protein Names

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase

Recombinant PFKFB3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71199	PFKFB3 Protein, Human (His)	Q16875 (M1-H520)	≥95%
HY-P74636	PFKFB3 Protein, Human (sf9, His-GST)	Q16875-1 (M1-H520)	≥95%

Related Diseases

Diseases

Alias

Colon Adenocarcinoma

Adenocarcinoma Of Colon	Adenocarcinoma Of The Colon
Colonic Adenocarcinoma

Glycogen Storage Disease

Glycogenosis	Glycogenoses
Gsd	Storage Disease, Glycogen
Gsd - [Glycogen Storage Disease]	Glycogen Thesaurismosis
Diffuse Glycogenosis	Generalised Glycogen Storage Disease
Generalised Glycogenosis	Generalised Glycogen Storage Disease Of Infants
Glycogen Synthase Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12203	PFK-158	Inducer	98.88%	Phase 1

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19824	3PO	Inhibitor	99.56%	Unkown
HY-12204	PFK-015	Inhibitor	99.80%	Unkown
HY-123981	5MPN		99.72%	Unkown
HY-101972	AZ-PFKFB3-67	Inhibitor	97.20%	Unkown
HY-101971	AZ PFKFB3 26	Inhibitor	99.23%	Unkown
HY-110156	YZ9		98.56%	Unkown
HY-112808	KAN0438757	Inhibitor	99.41%	Unkown
HY-153077	PFKFB3-IN-2	Inhibitor	99.53%	Unkown
HY-101972A	AZ-PFKFB3-67 quarterhydrate	Inhibitor	≥99.0%	Unkown
HY-RS10363	PFKFB3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PFKFB3	VGNC	VGNC:32771
Macaca mulatta	PFKFB3	VGNC	VGNC:75959
Felis catus	PFKFB3	VGNC	VGNC:68805
Canis familiaris	PFKFB3	VGNC	VGNC:44444
Rattus norvegicus	PFKFB3	RGD	RGD:619776
Mus musculus	PFKFB3	MGD	MGI:2181202
Others	PFKFB3	NCBI

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