2. Gene
  3. POLR2I - RNA polymerase II subunit I Gene

POLR2I - RNA polymerase II subunit I Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RPB9; hRPB14.5

Gene ID: 5438 | Gene type: protein coding

About POLR2I

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:36,113,709-36,114,875 (from NCBI)

This gene has 7 transcripts (splice variants), 192 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 23.3), brain (RPKM 15.2) and 25 other tissues.

Summary

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two Other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger motifs with conserved cysteines and the subunit does possess zinc binding activity. [provided by RefSeq, Jul 2008]

POLR2I Products(1)

mRNA Protein Name
NM_006233.5 NP_006224.1 DNA-directed RNA polymerase II subunit RPB9
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
Biological Process GO Annotation Evidence Reference Source
involved in transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9852112 GOA
Cellular Component GO Annotation Evidence Reference Source
part of RNA polymerase II, core complex IDA
IDA: Inferred from direct assay
9852112 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9852112 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLR2I Protein Structure

RNA_POL_M_15KD

RNA_POL_M_15KD: RNA polymerases M/15 Kd subunit (14 - 51)

TFIIS_C

TFIIS_C: Transcription factor S-II (TFIIS) (84 - 124)

  • 0
  • 100
  • 125 a.a.
Protein Preferred Names Protein Names

DNA-directed RNA polymerase II subunit RPB9

DNA-directed RNA polymerase II 14.5 kDa polypeptide

Related Diseases

Diseases Alias
Polyomavirus-Associated Nephropathy

Polyomavirus Associated Nephropathy

Pvan
Cockayne Syndrome A

Cockayne Syndrome Type 1

Cockayne Syndrome, Type A

Cockayne Syndrome Type I

CSA

Cockayne Syndrome Classic Form

Cockayne Syndrome Classical

Cockayne Syndrome Type A

Ckn1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10850 POLR2I Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris POLR2I VGNC VGNC:44798
Felis catus POLR2I VGNC VGNC:68954
Macaca mulatta POLR2I VGNC VGNC:76217
Bos taurus POLR2I VGNC VGNC:33143
Mus musculus POLR2I MGD MGI:1917170
Rattus norvegicus POLR2I RGD RGD:1309395