RHOF - ras homolog family member F, filopodia associated Gene

Homo sapiens

Also known as RIF; ARHF

Gene ID: 54509 | Gene type: protein coding

About RHOF

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:121,777,754-121,793,688 (from NCBI)

This gene has 7 transcripts (splice variants), 225 orthologues and 22 paralogues. Broad expression in lymph node (RPKM 15.7), bone marrow (RPKM 15.5) and 23 other tissues.

Summary

Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in actin filament organization. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

RHOF Products(1)

mRNA	Protein	Name
NM_019034.3	NP_061907.2	rho-related GTP-binding protein RhoF

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin filament organization	IDA IDA: Inferred from direct assay	11084341	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RHOF Protein Structure

Ras

0
100
211 a.a.

Protein Preferred Names

Protein Names

rho-related GTP-binding protein RhoF

ras homolog family member F (in filopodia)

Related Diseases

Diseases

Alias

Ascaridiasis

Ascariasis

Toxic Megacolon

Megacolon, Toxic	Toxic Dilatation Of Colon
Toxic Functional Megacolon

Deafness, Autosomal Recessive 104

DFNB104	Autosomal Recessive Nonsyndromic Deafness 104
Autosomal Recessive Deafness 104	Deafness, Autosomal Recessive, 104
Deafness, Autosomal Recessive, Type 104

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Premature Ovarian Failure 18

POF18	Primary Ovarian Insufficiency 18
Ovarian Failure, Premature, Type 18

Deafness, Autosomal Dominant 1, With Or Without Thrombocytopenia

Konigsmark Syndrome	DFNA1
Autosomal Dominant Nonsyndromic Deafness 1	Lfhl1
Deafness, Autosomal Dominant 1	Autosomal Dominant Deafness 1
Autosomal Dominant Deafness 1, With Or Without Thrombocytopenia	Hereditary Low Frequency Hearing Loss 1
Diaph1-Related Sensorineural Hearing Loss-Thrombocytopenia Syndrome	Diaph1-Related Sensorineural Deafness-Thrombocytopenia Syndrome
Hereditary Low-Frequency Hearing Loss	Hereditary Low-Frequency Sensorineural Hearing Loss
Lfsnhl1	Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 1
Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 1	Deafness, Autosomal Dominant, Type 1

Clostridium Difficile Colitis

Pseudomembranous Colitis	Colitis Pseudomembranous
Enterocolitis, Pseudomembranous	Pseudomembranous Enterocolitis
Clostridium Difficile Infection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11952	RHOF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RHOF	RGD	RGD:1584038
Canis familiaris	RHOF	VGNC	VGNC:45559
Mus musculus	RHOF	MGD	MGI:1345629
Felis catus	RHOF	VGNC	VGNC:64616
Macaca mulatta	RHOF	VGNC	VGNC:76739
Bos taurus	RHOF	VGNC	VGNC:33948

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