OXSM - 3-oxoacyl-ACP synthase, mitochondrial Gene

Homo sapiens

Also known as KS; CEM1; KASI; FASN2D

Gene ID: 54995 | Gene type: protein coding

About OXSM

Cytogenetic location: 3p24.2 Genomic coordinates (GRCh38): 3:25,790,090-25,794,531 (from NCBI)

This gene has 9 transcripts (splice variants), 201 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 3.3), thyroid (RPKM 1.6) and 25 other tissues.

Summary

This gene encodes a beta-ketoacyl synthetase. The encoded Enzyme is required for elongation of fatty acid chains in the mitochondria. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009]

OXSM Products(2)

mRNA	Protein	Name
NM_001145391.2	NP_001138863.1	3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform 2 precursor
NM_017897.3	NP_060367.1	3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity	IDA IDA: Inferred from direct assay	15668256	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in acyl-CoA metabolic process	IDA IDA: Inferred from direct assay	15668256	GOA
involved in medium-chain fatty acid biosynthetic process	IDA IDA: Inferred from direct assay	15668256	GOA
involved in short-chain fatty acid biosynthetic process	IDA IDA: Inferred from direct assay	15668256	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IMP IMP: Inferred from mutant phenotype	15668256	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OXSM Protein Structure

ketoacyl-synt

Ketoacyl-synt_C

0
100
200
300
400
459 a.a.

Protein Preferred Names

Protein Names

3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial

3-ketoacyl-acyl carrier protein synthase

Related Diseases

Diseases

Alias

Animal Phobia

Zoophobia

Fear Of Animals

Gaucher Disease, Type Iii

Gaucher Disease, Subacute Neuronopathic Type	Gd Iii
Gaucher Disease, Chronic Neuronopathic Type	Gaucher Disease, Juvenile And Adult, Cerebral
Gaucher Disease Type 3	GD3
Gaucher'S Disease Type Iii	Gaucher Disease Type Iii
Gd 3	Cerebral Juvenile And Adult Form Of Gaucher Disease
Chronic Neuronopathic Gaucher Disease	Gaucher Disease 3
Cerebral, Juvenile And Adult, Gaucher Disease	Gaucher Disease Chronic Neuronopathic Type
Gaucher Disease Type Ii	Subacute Neuronopathic Gaucher Disease
Type 3 Gaucher Disease	Gaucher Disease, Type 3
Gaucher Disease, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09891	OXSM Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	OXSM	VGNC	VGNC:32513
Canis familiaris	OXSM	VGNC	VGNC:44204
Felis catus	OXSM	VGNC	VGNC:102794
Rattus norvegicus	OXSM	RGD	RGD:1311092
Mus musculus	OXSM	MGD	MGI:1918397
Macaca mulatta	OXSM	VGNC	VGNC:75681

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