ARHGEF10L - Rho guanine nucleotide exchange factor 10 like Gene

Homo sapiens

Also known as GrinchGEF

Gene ID: 55160 | Gene type: protein coding

About ARHGEF10L

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:17,513,435-17,697,875 (from NCBI)

This gene has 9 transcripts (splice variants), 256 orthologues, 2 paralogues and is associated with 76 phenotypes. Ubiquitous expression in kidney (RPKM 7.7), colon (RPKM 6.9) and 24 other tissues.

Summary

This gene belongs to the RhoGEF subfamily of RhoGTPases. Members of this subfamily are activated by specific guanine nucleotide exchange factors (GEFs) and are involved in signal transduction. The encoded protein shows cytosolic distribution. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2016]

ARHGEF10L Products(5)

mRNA	Protein	Name
NM_001011722.2	NP_001011722.2	rho guanine nucleotide exchange factor 10-like protein isoform 2
NM_001319837.1	NP_001306766.1	rho guanine nucleotide exchange factor 10-like protein isoform 3
NM_001319838.1	NP_001306767.1	rho guanine nucleotide exchange factor 10-like protein isoform 4
NM_001328124.1	NP_001315053.1	rho guanine nucleotide exchange factor 10-like protein isoform 5
NM_018125.4	NP_060595.3	rho guanine nucleotide exchange factor 10-like protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activator activity	IDA IDA: Inferred from direct assay	16112081	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in SREBP signaling pathway	IDA IDA: Inferred from direct assay	16112081	GOA
involved in positive regulation of stress fiber assembly	IDA IDA: Inferred from direct assay	16112081	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	16112081	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGEF10L Protein Structure

RhoGEF

0
200
400
600
800
1000
1200
1279 a.a.

Protein Preferred Names

Protein Names

rho guanine nucleotide exchange factor 10-like protein

Rho guanine nucleotide exchange factor (GEF) 10-like

Related Diseases

Diseases

Alias

Post-Vaccinal Encephalitis

Encephalitis Following Immunization Procedures	Postvaccinal Encephalomyelitis
Encephalomyelitis, Acute Disseminated

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00947	ARHGEF10L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ARHGEF10L	VGNC	VGNC:38073
Macaca mulatta	ARHGEF10L	VGNC	VGNC:69908
Bos taurus	ARHGEF10L	VGNC	VGNC:26105
Rattus norvegicus	ARHGEF10L	RGD	RGD:1585585
Felis catus	ARHGEF10L	VGNC	VGNC:59897
Mus musculus	ARHGEF10L	MGD	MGI:1920004

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