2. Gene
  3. PRB1 - proline rich protein BstNI subfamily 1 Gene

PRB1 - proline rich protein BstNI subfamily 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PM; PMF; PMS; PRB1L; PRB1M

Gene ID: 5542 | Gene type: protein coding

About PRB1

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:11,351,821-11,355,591 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 21 orthologues and 6 paralogues. Restricted expression toward salivary gland (RPKM 6228.4).

Summary

This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature Peptides before secretion from the parotid glands. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the "Medium" allele. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Nov 2015]

PRB1 Products(2)

mRNA Protein Name
NM_001367912.2 NP_001354841.1 basic salivary proline-rich protein 1 isoform 4 precursor
NM_005039.4 NP_005030.2 basic salivary proline-rich protein 1 isoform 1 preproprotein

PRB1 Protein Structure

Pro-rich

Pro-rich: Proline-rich (1 - 94)

Pro-rich

Pro-rich: Proline-rich (87 - 198)

  • 0
  • 100
  • 198 a.a.
Protein Preferred Names Protein Names

basic salivary proline-rich protein 1

BstNI type basic salivary proline-rich protein 1

Related Diseases

Diseases Alias
Head And Neck Cancer

Head And Neck Neoplasm

Head And Neck Tumours

Head/Neck Neoplasm

Tumor Of Head And Neck

Head And Neck Neoplasms

Hnc

Cancer, Head/Neck
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-162318A MYC degrader 1 TFA Degrader 99.36% Unkown
HY-162318 MYC degrader 1 Degrader 99.61% Unkown
HY-RS11051 PRB1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PRB1 RGD RGD:628796