PRB4 - proline rich protein BstNI subfamily 4 Gene

Homo sapiens

Also known as Po

Gene ID: 5545 | Gene type: protein coding

About PRB4

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:11,307,077-11,310,436 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 6 orthologues and 6 paralogues. Restricted expression toward salivary gland (RPKM 1203.4).

Summary

This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature Peptides before secretion from the parotid glands. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the "Small" allele. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Nov 2015]

PRB4 Products(2)

mRNA	Protein	Name
NM_001261399.3	NP_001248328.1	basic salivary proline-rich protein 4 isoform 2 preproprotein
NM_002723.6	NP_002714.2	basic salivary proline-rich protein 4 isoform 1 preproprotein

PRB4 Protein Structure

Pro-rich

0
100
200
247 a.a.

Protein Preferred Names

Protein Names

basic salivary proline-rich protein 4

BstNI type basic salivary proline-rich protein 4

Related Diseases

Diseases

Alias

Hypogonadotropic Hypogonadism 6 With Or Without Anosmia

HH6	Kallmann Syndrome 6
Kal6	Hypogonadotropic Hypogonadism, Type 6 With/Without Anosmia

Head And Neck Cancer

Head And Neck Neoplasm	Head And Neck Tumours
Head/Neck Neoplasm	Tumor Of Head And Neck
Head And Neck Neoplasms	Hnc
Cancer, Head/Neck

Bilateral Renal Aplasia

Hypopharynx Cancer

Hypopharyngeal Cancer	Malignant Neoplasm Of Hypopharynx
Hypopharyngeal Neoplasms	Hypopharyngeal Carcinoma
Malignant Hypopharyngeal Tumor	Malignant Tumor Of Hypopharynx
Malignant Tumour Of Hypopharynx

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11054	PRB4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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