PRH2 - proline rich protein HaeIII subfamily 2 Gene

Homo sapiens

Also known as Pr; pr1/Pr2; PRP-1/PRP-2

Gene ID: 5555 | Gene type: protein coding

About PRH2

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,929,236-10,934,845 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 10 orthologues and 6 paralogues. Restricted expression toward salivary gland (RPKM 6639.8).

Summary

This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. In western population this locus is commonly biallelic and encodes proline-rich protein (PRP) isoforms, PRP-1 and PRP-2. The reference genome encodes the PRP-1 allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Oct 2015]

PRH2 Products(1)

mRNA	Protein	Name
NM_001110213.1	NP_001103683.1	salivary acidic proline-rich phosphoprotein 1月2日 preproprotein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16203048	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRH2 Protein Structure

Pro-rich

0
100
166 a.a.

Protein Preferred Names

Protein Names

salivary acidic proline-rich phosphoprotein 1/2

acidic salivary proline-rich protein, HaeIII type, 2

Related Diseases

Diseases

Alias

Dental Caries

Dental Caries Extending Into Pulp	Dental Caries Of Smooth Surface
Dental Caries Pit And Fissure	Smooth Surface Dental Caries
Dental Decay	Carious Teeth
Dental Cavity	Saprodontia
Teeth Decayed	Tooth Caries
Tooth Decay

Retinitis Pigmentosa 35

RP35	Retinitis Pigmentosa-35
Retinitis Pigmentosa, Type 35

Ulna And Fibula, Absence Of, With Severe Limb Deficiency

Schinzel Phocomelia Syndrome	Aarrs
Limb/Pelvis-Hypoplasia/Aplasia Syndrome	LPHAS
Schinzel Type Phocomelia	Absence Of Ulna And Fibula With Severe Limb Deficiency
Al-Awadi/Raas-Rothschild Syndrome	Al Awadi-Raas-Rothschild Syndrome
Al-Awadi/Raas-Rothschild/Schinzel Phocomelia Syndrome	Aplasia/Hypoplasia Of Limbs And Pelvis
Congenital Absence Of Ulna And Fibula	Severe Limb Deficit
Phocomelia, Schinzel Type	Al-Awadi-Raas-Rothschild Syndrome
Ulna And Fibula Absence Of With Severe Limb Deficiency	Limb Pelvis Hypoplasia Aplasia Syndrome
Limb/Pelvis/Uterus-Hypoplasia/Aplasia Syndrome	Ulna And Fibula, Absence Of, With Sever Limb Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11092	PRH2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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